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Ligands
Code Name Style Show Link
YNC Tetradec-13-ynoic acid - CoA thioester
JCY 1-(5-{4-fluoro-2-[2-(1,3,5-trimethyl-1h-pyrazol-4-yl)ethoxy]phenyl}-1-methyl-1h-indazol-3-yl)-N,N-dimethylmethanamine
SO4 Sulfate ion
CL Chloride ion
Non-standard Residues
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Glycosylation
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Code : 6MB0   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of N-myristoyl transferase (NMT) G386E mutant from Plasmodium vivax in complex with inhibitor IMP-1002
Release Data : 2019-06-05
Compound :
mol_id molecule chains
1 Glycylpeptide N-tetradecanoyltransferase A,B,C
ec: 2.3.1.97
mutation: G386E
Source :
mol_id organism_scientific expression_system
1 Plasmodium vivax  (taxid:5855) Escherichia coli  (taxid:469008)
gene: PVC01_130042700, PVP01_1336100
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: PlviB.18219.a.FR21
Authors : Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Keywords : SSGCID, glycylpeptide N-tetradecanoyltransferase, N-myristoyltransferase, NMT, Salvador I, Structural Genomics, Seattle Structural Genomics Center for Infectious Disease, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.5500 Å )
Citation :

Structure-Guided Identification of Resistance Breaking Antimalarial N‐Myristoyltransferase Inhibitors.

Schlott, A.C.,Mayclin, S.,Reers, A.R.  et al.
(2019)  Cell Chem Biol  26 : 991

PubMed: 31080074
DOI: 10.1016/j.chembiol.2019.03.015

Chain : A, B, C
UniProt : A0A1G4HIY1 (A0A1G4HIY1_PLAVI)
Reaction: EC: Evidence:
Physiological Direction:
N-terminal glycyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoylglycyl-[protein] 2.3.1.97 RuleBase:RU000586
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