Brand  (β version)

PDB ID: 6MAE

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Ligands
Code Name Style Show Link
JBA (2r)-3-{(5s)-3-[4-(cyclopropylethynyl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}-N-hydroxy-2-methyl-2-(methylsulfonyl)propanamide PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 6MAE   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : CHAIN A. UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase PA-LPXC Complexed with (R)-3-((S)-3-(4-(cyclopropylethynyl)phenyl)-2-oxooxazolidin-5-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)propenamide
Release Data : 2019-01-23
Compound :
mol_id molecule chains synonym
1 UDP-3-O-acyl-N-acetylglucosamine deacetylase A UDP-3-O-acyl-GlcNAc deacetylase,UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase
ec: 3.5.1.108
Source :
mol_id organism_scientific
1 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)  (taxid:208964)
strain: ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1
Authors : Shu, W.
Keywords : LPXC, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.8000 Å )
Citation :

Application of Virtual Screening to the Identification of New LpxC Inhibitor Chemotypes, Oxazolidinone and Isoxazoline.

Lee, P.S.,Lapointe, G.,Madera, A.M.  et al.
(2018)  J. Med. Chem.  61 : 9360 - 9370

PubMed: 30226381
DOI: 10.1021/acs.jmedchem.8b01287

Reaction

Chain : A
UniProt : P47205 (LPXC_PSEAE)
Reaction: EC: Evidence:
Physiological Direction:
a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + H2O = a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate 3.5.1.108 HAMAP-Rule:MF_00388, PubMed:9068651
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