Brand  (β version)

PDB ID: 6M9T

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Ligands
Code Name Style Show Link
J9P (11alpha,12alpha,13e,16s)-11,16-dihydroxy-16-methyl-9-oxoprost-13-en-1-oic acid PoSSuM
OLA Oleic acid PoSSuM
OLC (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 6M9T   PDBj   RCSB PDB   PDBe
Header : MEMBRANE PROTEIN
Title : Crystal structure of EP3 receptor bound to misoprostol-FA
Release Data : 2018-12-05
Compound :
mol_id molecule chains synonym
1 Prostaglandin E2 receptor EP3 subtype, Endolysin chimera A PGE2 receptor EP3 subtype,PGE2-R,Prostanoid EP3 receptor,Lysis protein,Lysozyme,Muramidase
ec: 3.2.1.17
fragment: EP3 UNP residues 2-259,273-353 with intervening lysozyme
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: PTGER3
expression_system_common: Fall armyworm
Authors : Audet, M., White, K.L., Breton, B., Zarzycka, B., Han, G.W., Lu, Y., Gati, C., Batyuk, A., Popov, P., Velasquez, J., Manahan, D., Hu, H., Weierstall, U., Liu, W., Shui, W., Katrich, V., Cherezov, V., Hanson, M.A., Stevens, R.C.
Keywords : GPCR, prostaglandin E2 receptor 3 (EP3), prostaglandin analogue, membrane protein, misoprostol-FA (biologically active free acid), XFEL, LCP, T4L
Exp. method : X-RAY DIFFRACTION ( 2.50 Å )
Citation :

Crystal structure of misoprostol bound to the labor inducer prostaglandin E2receptor.

Audet, M.,White, K.L.,Breton, B.  et al.
(2019)  Nat. Chem. Biol.  15 : 11 - 17

PubMed: 30510194
DOI: 10.1038/s41589-018-0160-y

Reaction

Chain : A
UniProt : P43115 (PE2R3_HUMAN)
Reaction : -
Chain : A
UniProt : P00720 (ENLYS_BPT4)
Reaction: EC: Evidence:
Physiological Direction:
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. 3.2.1.17 HAMAP-Rule:MF_04110, PubMed:4865643
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