Brand  (β version)

PDB ID: 6M9D

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Ligands
Code Name Style Show Link
CA Calcium ion PoSSuM
Non-standard Residues
Code Name Show
PHL L-phenylalaninol
Glycosylation
Code Name Emphasize
Modification
Code Name Show
CSI Amino-(2-imino-hexahydro-pyrimidin-4-yl)-acetic acid

Structure summary

Code : 6M9D   PDBj   RCSB PDB   PDBe
Header : Hydrolase/Hydrolase inhibitor
Title : PSEUDOMONAS SERINE-CARBOXYL PROTEINASE (SEDOLISIN) COMPLEXED WITH THE INHIBITOR Chymostatin
Release Data : 2018-10-24
Compound :
mol_id molecule chains synonym
1 SEDOLISIN A Pepstatin-insensitive carboxyl proteinase,Pseudomonapepsin, Pseudomonalisin
ec: 3.4.21.100
mol_id molecule chains
2 Chymostatin A B
other_details: The first residue (PHE) of the inhibitor chymostatin A was not visible in the electron density map and is not modeled in the structure
Source :
mol_id organism_scientific expression_system
1 Pseudomonas sp. (strain 101)  (taxid:33067) Escherichia coli  (taxid:562)
strain: 101
gene: pcp
mol_id organism_scientific
2 Synthetic construct  (taxid:32630)
synthetic: yes
Authors : Wlodawer, A., Li, M., Gustchina, A., Dauter, Z., Uchida, K., Oyama, H., Goldfarb, N.E., Dunn, B.M., Oda, K.
Keywords : Serine-carboxyl proteinase, Hydrolase-hydrolase inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

Inhibitor complexes of the Pseudomonas serine-carboxyl proteinase

Wlodawer, A.,Li, M.,Gustchina, A.  et al.
(2001)  Biochemistry  40 : 15602 - 15611

PubMed: 11747435
DOI: 10.1021/bi011817n

Reaction

Chain : A
UniProt : P42790 (PICP_PSESR)
Reaction: EC: Evidence:
Physiological Direction:
Hydrolysis of the B chain of insulin at 13-Glu-|-Ala-14, 15- Leu-|-Tyr-16 and 25-Phe-|-Tyr-26 and angiotensin I at 4-Tyr-|-Ile-5. A good synthetic substrate is Lys-Pro-Ile-Glu-Phe-|-Phe(NO2)-Arg- Leu. 3.4.21.100 -
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