Brand  (β version)

PDB ID: 6M8E

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Ligands
Code Name Style Show Link
J8G 2-(3,4-dihydroxyphenyl)-3,5-dihydroxy-7-methoxy-4h-1-benzopyran-4-one PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 6M8E   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE Inhibitor
Title : Crystal structure of the core catalytic domain of human inositol phosphate multikinase in complex with rhamnetin
Release Data : 2019-01-23
Compound :
mol_id molecule chains synonym
1 Inositol polyphosphate multikinase,Inositol polyphosphate multikinase A Inositol 1,3,4,6-tetrakisphosphate 5-kinase,Inositol 1,3,4,6-tetrakisphosphate 5-kinase
ec: 2.7.1.151,2.7.1.151
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: IPMK, IMPK
Authors : Wang, H., Shears, S.B.
Keywords : kinase, inositol, inositol polyphosphate, TRANSFERASE, rhamnetin, flavonoid, inhibitor, natural product, TRANSFERASE-TRANSFERASE Inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

Inhibition of Inositol Polyphosphate Kinases by Quercetin and Related Flavonoids: A Structure-Activity Analysis.

Gu, C.,Stashko, M.A.,Puhl-Rubio, A.C.  et al.
(2019)  J. Med. Chem.  62 : 1443 - 1454

PubMed: 30624931
DOI: 10.1021/acs.jmedchem.8b01593

Reaction

Chain : A
UniProt : Q8NFU5 (IPMK_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
1D-myo-inositol 1,4,5-trisphosphate + 2 ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 2 ADP + 2 H(+) 2.7.1.151 PubMed:12027805, PubMed:12223481, PubMed:28882892, PubMed:30624931
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1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP = 1D-myo- inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+) 2.7.1.140 PubMed:12223481
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1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero- 3-phospho-1D-myo-inositol 4,5-bisphosphate + ATP = 1-octadecanoyl-2- (5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo- inositol 3,4,5-triphosphate) + ADP + H(+) - PubMed:28882892, PubMed:30420721
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a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5- bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol-3,4,5-trisphosphate) + ADP + H(+) 2.7.1.153 UniProtKB:Q99NI4
left-to-right
1D-myo-inositol 1,4,5,6-tetrakisphosphate + ATP = 1D-myo- inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+) - UniProtKB:Q99NI4
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Cofactor: Evidence: Note:
Mg(2+) ECO:0000305 | PubMed:28882892
ECO:0000305 | PubMed:30624931
Binds two Mg(2+), but the interaction with the protein is mostly indirect.