Brand  (β version)

PDB ID: 6M7V

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Ligands
Code Name Style Show Link
DZ4 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine PoSSuM
MN Manganese (II) ion PoSSuM
NI Nickel (II) ion PoSSuM
Non-standard Residues
Code Name Show
02I (6s,7s,8s,10r)-4-amino-8-hydroxy-7,8,9,10-tetrahydro-6h-7,10-epoxyazepino[1,2-E]purin-6-yl dihydrogen phosphate
Glycosylation
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Modification
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Structure summary

Code : 6M7V   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/DNA
Title : Human DNA polymerase eta extension complex with cdA at the -1 position
Release Data : 2018-09-12
Compound :
mol_id molecule chains synonym
1 DNA polymerase eta A RAD30 homolog A,Xeroderma pigmentosum variant type protein
ec: 2.7.7.7
mol_id molecule chains
2 DNA (5'-D(P*GP*TP*GP*TP*GP*AP*GP*T)-3') P
mol_id molecule chains
3 DNA (5'-D(P*(02I)P*CP*TP*CP*AP*CP*AP*CP*T)-3') T
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: POLH, RAD30, RAD30A, XPV
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
synthetic: yes
mol_id organism_scientific organism_common
3 Homo sapiens  (taxid:9606) Human
synthetic: yes
Authors : Weng, P., Gao, Y., Yang, W.
Keywords : TRANSLESION SYNTHESIS, HUMAN DNA POLYMERSE ETA cdA, TRANSFERASE-DNA complex
Exp. method : X-RAY DIFFRACTION ( 3.062 Å )
Citation :

Bypassing a 8,5'-cyclo-2'-deoxyadenosine lesion by human DNA polymerase eta at atomic resolution.

Weng, P.J.,Gao, Y.,Gregory, M.T.  et al.
(2018)  Proc. Natl. Acad. Sci. U.S.A.  115 : 10660 - 10665

PubMed: 30275308
DOI: 10.1073/pnas.1812856115

Reaction

Chain : A
UniProt : Q9Y253 (POLH_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) 2.7.7.7 PubMed:27284197
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