Brand  (β version)

PDB ID: 6LFF

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Ligands
Code Name Style Show Link
Non-standard Residues
Code Name Show
C7R 2'-deoxy-5'-O-thiophosphonocytidine
PST Thymidine-5'-thiophosphate
AS 2-deoxy-adenosine -5'-thio-monophosphate
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 6LFF   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION/DNA
Title : transcription factor SATB1 CUTr1 domain in complex with a phosphorothioate DNA
Release Data : 2020-04-01
Compound :
mol_id molecule chains synonym
1 DNA-binding protein SATB1 A,B transcription factor SATB1,Special AT-rich sequence-binding protein 1
mol_id molecule chains
2 DNA (5'-D(*GP*(C7R)P*(PST)P*AP*AP*TP*AP*TP*AP*TP*GP*C)-3') C
mol_id molecule chains
3 DNA (5'-D(*GP*CP*AP*TP*(AS)P*(PST)P*(AS)P*(PST)P*TP*AP*GP*C)-3') D
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: SATB1
expression_system_strain: BL21(DE3)
mol_id organism_scientific
2 Synthetic construct  (taxid:32630)
synthetic: yes
mol_id organism_scientific
3 Synthetic construct  (taxid:32630)
synthetic: yes
Authors : Akutsu, Y., Kubota, T., Yamasaki, T., Yamasaki, K.
Keywords : DNA-binding protein, DNA modification, Transcription factor, TRANSCRIPTION, TRANSCRIPTION-DNA complex
Exp. method : X-RAY DIFFRACTION ( 1.79 Å )
Citation :

Enhanced affinity of racemic phosphorothioate DNA with transcription factor SATB1 arising from diastereomer-specific hydrogen bonds and hydrophobic contacts.

Yamasaki, K.,Akutsu, Y.,Yamasaki, T.  et al.
(2020)  Nucleic Acids Res.  48 : 4551 - 4561

PubMed: 32187371
DOI: 10.1093/nar/gkaa170

Reaction

Chain : A, B
UniProt : Q01826 (SATB1_HUMAN)
Reaction : -