Het-PDB Navi2 (PDB: 6KJV)

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Ligands
Code	Name		Style	Show	Link
97Y	N-{4-[(R)-(3,3-dimethylcyclobutyl)({6-[4-(trifluoromethyl)-1h-imidazol-1-yl]pyridin-3-yl}amino)methyl]benzene-1-carbonyl}-beta-alanine				PoSSuM
OLC	(2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 6KJV

Code :

6KJV PDBj RCSB PDB PDBe

Header :

SIGNALING PROTEIN

Title :

Structure of thermal-stabilised(M9) human GLP-1 receptor transmembrane domain

Release Data :

2019-11-13

Compound :

mol_id	molecule	chains	synonym
1	Glucagon-like peptide 1 receptor,Endolysin,Glucagon-like peptide 1 receptor	A,B	GLP-1R,Lysis protein,Lysozyme,Muramidase,GLP-1R
	mutation: S193C,I196F,S225A,S271A,I317C,G318I,K346A,C347F,G361C,205-214deletion,R1011G,C1053T,C1096A,I1136R

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera aff. frugiperda 1 BOLD-2017 (taxid:2449148)
	gene: GLP1R expression_system_cell_line: IPLB-Sf-21-AE expression_system_cell: SF9 expression_system_plasmid: pfasctbac

Authors :

Song, G.

Keywords :

GPCR, seven-transmembrane, allosteric modulators, diabetes, SIGNALING PROTEIN

Exp. method :

X-RAY DIFFRACTION ( 2.8000 Å )

Citation :

Mutagenesis facilitated crystallization of GLP-1R.

Xu, Y.,Wang, Y.,Wang, Y. et al.
(2019) Iucrj 6 : 996 - 1006

Chain :

A, B

UniProt :

P00720 (ENLYS_BPT4)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.	3.2.1.17	HAMAP-Rule:MF_04110, PubMed:4865643
	-	HAMAP-Rule:MF_04110, PubMed:4865643

PDB ID: 6KJV