Het-PDB Navi2 (PDB: 6K1S)

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Ligands
Code	Name	Link
CUX	2-[[7-[(2~{R},3~{R},4~{S},5~{R})-5-[(~{R})-(4-chlorophenyl)-oxidanyl-methyl]-3,4-bis(oxidanyl)oxolan-2-yl]pyrrolo[2,3-D]pyrimidin-4-yl]amino]ethanal	PoSSuM
DMS	Dimethyl sulfoxide	PoSSuM
EDO	1,2-ethanediol	PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 6K1S

Code :

6K1S PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Discovery of Potent and Selective Covalent Protein Arginine Methyltransferase (PRMT5) Inhibitors

Release Data :

2019-06-19

Compound :

mol_id	molecule	chains	synonym
1	Protein arginine N-methyltransferase 5	A	72 kDa ICln-binding protein,Histone-arginine N-methyltransferase PRMT5,Jak-binding protein 1,Shk1 kinase-binding protein 1 homolog,SKB1Hs
	ec: 2.1.1.320

mol_id	molecule	chains	synonym
2	Methylosome protein 50	B	MEP-50,Androgen receptor cofactor p44,WD repeat-containing protein 77,p44/Mep50

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: PRMT5, HRMT1L5, IBP72, JBP1, SKB1

mol_id	organism_scientific	organism_common	expression_system
2	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: WDR77, MEP50, WD45, HKMT1069, Nbla10071

Authors :

Tong, S., Lin, H.

Keywords :

PRMT5, complex, covalent, inhibitor, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 2.60 Å )

Citation :

Discovery of Potent and Selective Covalent Protein Arginine Methyltransferase 5 (PRMT5) Inhibitors.

Lin, H.,Wang, M.,Zhang, Y.W. et al.
(2019) Acs Med.Chem.Lett. 10 : 1033 - 1038

Chain :

UniProt :

O14744 (ANM5_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L- homocysteine + 2 H(+)	2.1.1.320	PubMed:19011621, PubMed:21081503, PubMed:23071334
	-	PubMed:19011621, PubMed:21081503, PubMed:23071334

PDB ID: 6K1S