PDB ID: 6K1S
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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CUX | 2-[[7-[(2~{R},3~{R},4~{S},5~{R})-5-[(~{R})-(4-chlorophenyl)-oxidanyl-methyl]-3,4-bis(oxidanyl)oxolan-2-yl]pyrrolo[2,3-D]pyrimidin-4-yl]amino]ethanal | PoSSuM | |||
DMS | Dimethyl sulfoxide | PoSSuM | |||
EDO | 1,2-ethanediol | PoSSuM |
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Download interaction data: 6K1S
Structure summary
Code : | 6K1S PDBj RCSB PDB PDBe | ||||||||||||||||||||||||
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Header : | TRANSFERASE | ||||||||||||||||||||||||
Title : | Discovery of Potent and Selective Covalent Protein Arginine Methyltransferase (PRMT5) Inhibitors | ||||||||||||||||||||||||
Release Data : | 2019-06-19 | ||||||||||||||||||||||||
Compound : |
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Source : |
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Authors : | Tong, S., Lin, H. | ||||||||||||||||||||||||
Keywords : | PRMT5, complex, covalent, inhibitor, TRANSFERASE | ||||||||||||||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.60 Å ) | ||||||||||||||||||||||||
Citation : |
Discovery of Potent and Selective Covalent Protein Arginine Methyltransferase 5 (PRMT5) Inhibitors.
Lin, H.,Wang, M.,Zhang, Y.W.
et al.
PubMed: 31312404 |
Reaction
Chain : | A | ||||||||
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UniProt : | O14744 (ANM5_HUMAN) | ||||||||
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Chain : | B |
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UniProt : | Q9BQA1 (MEP50_HUMAN) |
Reaction : | - |