Het-PDB Navi2 (PDB: 6K04)

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Ligands
Code	Name		Style	Show	Link
CQF	(6~{R})-~{N}-(4-chlorophenyl)-1-methyl-8-(1-methylpyrazol-4-yl)-5,6-dihydro-4~{H}-[1,2,4]triazolo[4,3-a][1]benzazepin-6-amine				PoSSuM

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Download interaction data: 6K04

Code :

6K04 PDBj RCSB PDB PDBe

Header :

ANTITUMOR PROTEIN

Title :

Crystal structure of BRD2(BD2)with ligand BY27 bound

Release Data :

2019-09-18

Compound :

mol_id	molecule	chains	synonym
1	Bromodomain-containing protein 2	A	O27.1.1,Really interesting new gene 3 protein

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: BRD2, KIAA9001, RING3

Authors :

Lu, T., Lu, W., Chen, D., Zhao, Y., Luo, C.

Keywords :

Antitumor; BET proteins; Bromodomain inhibitor; Epigenetic readers, ANTITUMOR PROTEIN

Exp. method :

X-RAY DIFFRACTION ( 1.251 Å )

Citation :

Discovery, structural insight, and bioactivities of BY27 as a selective inhibitor of the second bromodomains of BET proteins.

Chen, D.,Lu, T.,Yan, Z. et al.
(2019) Eur.J.Med.Chem. 182 : 111633 - 111633

PDB ID: 6K04