Brand  (β version)

PDB ID: 6JUT

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Ligands
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C9O ~{N}-[2,4-bis(fluoranyl)-3-[4-(3-methoxy-1~{H}-pyrazolo[3,4-B]pyridin-5-yl)-1,2,3-triazol-1-yl]phenyl]-3-bromanyl-benzenesulfonamide PoSSuM
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Structure summary

Code : 6JUT   PDBj   RCSB PDB   PDBe
Header : STRUCTURAL PROTEIN
Title : Crystal structure of ZAK in complex with compound 6k
Release Data : 2019-07-24
Compound :
mol_id molecule chains
1 Mitogen-activated protein kinase kinase kinase MLT A
ec: 2.7.11.25
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: ZAK
Authors : Kong, L.L., Yun, C.H.
Keywords : ZAK, Inhibitor, STRUCTURAL PROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.1 Å )
Citation :

Design, Synthesis, and Structure-Activity Relationships of 1,2,3-Triazole Benzenesulfonamides as New Selective Leucine-Zipper and Sterile-alpha Motif Kinase (ZAK) Inhibitors.

Yang, J.,Shibu, M.A.,Kong, L.  et al.
(2020)  J.Med.Chem.  63 : 2114 - 2130

PubMed: 31244114
DOI: 10.1021/acs.jmedchem.9b00664

Reaction

Chain : A
UniProt : Q9NYL2 (M3K20_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.25 PubMed:11836244, PubMed:14521931, PubMed:26999302, PubMed:32289254, PubMed:32610081, PubMed:35857590
left-to-right
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.25 PubMed:11836244, PubMed:14521931, PubMed:26999302, PubMed:32289254, PubMed:32610081, PubMed:35857590
left-to-right PubMed:11836244, PubMed:14521931, PubMed:26999302, PubMed:32289254, PubMed:32610081, PubMed:35857590