PDB ID: 6JSE
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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C6R | N-[3-[(4s,5r)-2-azanyl-4-methyl-5-phenyl-5,6-dihydro-1,3-thiazin-4-yl]-4-fluoranyl-phenyl]-5-(fluoranylmethoxy)pyrazine-2-carboxamide | PoSSuM | |||
DMS | Dimethyl sulfoxide | PoSSuM | |||
IOD | Iodide ion | PoSSuM |
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Download interaction data: 6JSE
Structure summary
Code : | 6JSE PDBj RCSB PDB PDBe | ||||||||||||
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Header : | HYDROLASE | ||||||||||||
Title : | Crystal Structure of BACE1 in complex with N-(3-((4S,5R)-2-amino-4-methyl-5-phenyl-5,6-dihydro-4H-1,3-thiazin-4-yl)-4-fluorophenyl)-5-(fluoromethoxy)pyrazine-2-carboxamide | ||||||||||||
Release Data : | 2019-08-28 | ||||||||||||
Compound : |
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Authors : | Fujimoto, K., Matsuoka, E., Asada, N., Tadano, G., Yamamoto, T., Nakahara, K., Fuchino, K., Ito, H., Kanegawa, N., Moechars, D., Gijsen, H.J.M., Kusakabe, K.I. | ||||||||||||
Keywords : | GS-hBACE1(43-454), HYDROLASE | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.0000 Å ) | ||||||||||||
Citation : |
Structure-Based Design of Selective beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: Targeting the Flap to Gain Selectivity over BACE2.
Fujimoto, K.,Matsuoka, E.,Asada, N.
et al.
PubMed: 31021626 |
Reaction
Chain : | A | ||||||||
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UniProt : | P56817 (BACE1_HUMAN) | ||||||||
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