Het-PDB Navi2 (PDB: 6JRX)

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Ligands
Code	Name		Style	Show	Link
9JO	N-{trans-4-[3-(2-chlorophenyl)-7-{[3-methyl-4-(4-methylpiperazin-1-yl)phenyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-D]pyrimidin-1(2h)-yl]cyclohexyl}propanamide				PoSSuM

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Download interaction data: 6JRX

Code :

6JRX PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

EGFR T790M/C797S in complex with compound 6i

Release Data :

2020-04-15

Compound :

mol_id	molecule	chains	synonym
1	Epidermal growth factor receptor	A	Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1
	ec: 2.7.10.1 mutation: T790M, C797S

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: EGFR, ERBB, ERBB1, HER1

Authors :

Zhu, S.J., Yun, C.H.

Keywords :

EGFR T790M/C797S, Inhibitor, Complex, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 2.201 Å )

Citation :

Design, Synthesis, and Structure-Activity Relationships of 1,2,3-Triazole Benzenesulfonamides as New Selective Leucine-Zipper and Sterile-alpha Motif Kinase (ZAK) Inhibitors.

Yang, J.,Shibu, M.A.,Kong, L. et al.
(2020) J.Med.Chem. 63 : 2114 - 2130

PubMed: 31244114
DOI: 10.1021/acs.jmedchem.9b00664

Chain :

UniProt :

P00533 (EGFR_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]	2.7.10.1	PROSITE-ProRule:PRU10028, PubMed:15374980, PubMed:17349580, PubMed:18046415, PubMed:18227510, PubMed:19560417, PubMed:19563760
	-

PDB ID: 6JRX

Hetero Atom Contents

Structure summary

Reaction