Brand  (β version)

PDB ID: 6JQO

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Ligands
Code Name Style Show Link
COO Crotonyl coenzyme a PoSSuM
NAP Nadp nicotinamide-adenine-dinucleotide phosphate PoSSuM
Non-standard Residues
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Glycosylation
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Modification
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Structure summary

Code : 6JQO   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Structure of PaaZ, a bifunctional enzyme in complex with NADP+ and CCoA
Release Data : 2019-09-11
Compound :
mol_id molecule chains
1 Bifunctional protein PaaZ A,B,C,D,E,F
ec: 3.3.2.12,1.2.1.91
Source :
mol_id organism_scientific expression_system
1 Escherichia coli K-12  (taxid:83333) Escherichia coli BL21(DE3)  (taxid:469008)
strain: K-12
gene: paaZ
expression_system_strain: BL21(DE3)
Authors : Gakher, L., Vinothkumar, K.R., Katagihallimath, N., Sowdhamini, R., Sathyanarayanan, N., Cannone, G.
Keywords : substrate channeling, bi-functional enzyme, hydrolase, dehydrogenase
Exp. method : ELECTRON MICROSCOPY ( 3.1 Å )
Citation :

Molecular basis for metabolite channeling in a ring opening enzyme of the phenylacetate degradation pathway.

Sathyanarayanan, N.,Cannone, G.,Gakhar, L.  et al.
(2019)  Nat Commun  10 : 4127 - 4127

PubMed: 31511507
DOI: 10.1038/s41467-019-11931-1

Reaction

Chain : A, B, C, D, E, F
UniProt : P77455 (PAAZ_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
2-oxepin-2(3H)-ylideneacetyl-CoA + H2O = 3-oxo-5,6- dehydrosuberyl-CoA semialdehyde 3.3.2.12 PubMed:21296885
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3-oxo-5,6-dehydrosuberyl-CoA semialdehyde + H2O + NADP(+) = 3- oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH 1.2.1.91 PubMed:21296885
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