Brand  (β version)

PDB ID: 6JPW

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Structure summary

Code : 6JPW   PDBj   RCSB PDB   PDBe
Header : VIRAL PROTEIN
Title : Crystal structure of Zika NS2B-NS3 protease with compound 1C
Release Data : 2019-06-26
Compound :
mol_id molecule chains synonym
1 Serine protease subunit NS2B A,C,E,G NS2B cofactor
ec: 3.4.21.91,3.6.1.15,3.6.4.13,2.1.1.56,2.1.1.57,2.7.7.48
mol_id molecule chains
2 NS3 protease B,D,F,H
mol_id molecule chains
3 SER-C0F-GLY-LYS-ARG-LYS J,K,L
Source :
mol_id organism_scientific organism_common expression_system
1 Zika virus  (taxid:64320) ZIKV Escherichia coli  (taxid:562)
mol_id organism_scientific organism_common expression_system
2 Zika virus (strain Mr 766)  (taxid:64320) ZIKV Escherichia coli  (taxid:562)
strain: Mr 766
gene: GP1, A2G93_63394gpGP1
mol_id organism_scientific
3 Synthetic construct  (taxid:32630)
synthetic: yes
Authors : Quek, J.P.
Keywords : Viral protease, Protease inhibitor complex, VIRAL PROTEIN
Exp. method : X-RAY DIFFRACTION ( 1.951 Å )
Citation :

Biocompatible Macrocyclization between Cysteine and 2-Cyanopyridine Generates Stable Peptide Inhibitors.

Nitsche, C.,Onagi, H.,Quek, J.P.  et al.
(2019)  Org.Lett.  21 : 4709 - 4712

PubMed: 31188009
DOI: 10.1021/acs.orglett.9b01545

Reaction

Chain : A, C, E, G
UniProt : Q32ZE1 (POLG_ZIKV)
Reaction: EC: Evidence:
Physiological Direction:
Selective hydrolysis of -Xaa-Xaa-|-Yaa- bonds in which each of the Xaa can be either Arg or Lys and Yaa can be either Ser or Ala. 3.4.21.91 -
-
a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1) 2.7.7.48 PROSITE-ProRule:PRU00539, PubMed:31090058
-
a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'- diphosphate + H(+) + phosphate 3.6.1.15 -
-
ATP + H2O = ADP + H(+) + phosphate 3.6.4.13 UniProtKB:Q9Q6P4
-
a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'- triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L- homocysteine 2.1.1.56 PROSITE- ProRule:PRU00924
-
a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'- triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA + H(+) + S- adenosyl-L-homocysteine 2.1.1.57 PROSITE-ProRule:PRU00924
-
Chain : B, D, F, H
UniProt : A0A142IX72 (A0A142IX72_ZIKV)
Reaction: EC: Evidence:
Physiological Direction:
ATP + H2O = ADP + H(+) + phosphate 3.6.4.13 ARBA:ARBA00001556
-
Selective hydrolysis of -Xaa-Xaa-|-Yaa- bonds in which each of the Xaa can be either Arg or Lys and Yaa can be either Ser or Ala. 3.4.21.91 ARBA:ARBA00024468
-
a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'- diphosphate + H(+) + phosphate 3.6.1.15 ARBA:ARBA00001491
-