Het-PDB Navi2 (PDB: 6JMF)

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Ligands
Code	Name		Style	Show	Link
9FC	6-{[(1r,2s)-2-aminocyclohexyl]amino}-5-cyano-2-[(3-methylphenyl)amino]pyridine-3-carboxamide				PoSSuM
SO4	Sulfate ion				PoSSuM

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Download interaction data: 6JMF

Code :

6JMF PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Crystal structure of human tyrosine-protein kinase Fes/Fps in complex with compound 4

Release Data :

2019-06-12

Compound :

mol_id	molecule	chains	synonym
1	Tyrosine-protein kinase Fes/Fps	A	Feline sarcoma/Fujinami avian sarcoma oncogene homolog,Proto-oncogene c-Fes,Proto-oncogene c-Fps,p93c-fes
	ec: 2.7.10.2

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: FES, FPS

Authors :

Baba, D., Hanzawa, H.

Keywords :

FES, c-Fes, tyrosine protein kinase, transferase

Exp. method :

X-RAY DIFFRACTION ( 2.00 Å )

Citation :

Discovery of Novel Pyrido-pyridazinone Derivatives as FER Tyrosine Kinase Inhibitors with Antitumor Activity.

Taniguchi, T.,Inagaki, H.,Baba, D. et al.
(2019) Acs Med.Chem.Lett. 10 : 737 - 742

Chain :

UniProt :

P07332 (FES_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]	2.7.10.2	PROSITE-ProRule:PRU10028, PubMed:11509660, PubMed:15485904, PubMed:15867340, PubMed:18775312, PubMed:2656706, PubMed:7687763
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PDB ID: 6JMF