Brand  (β version)

PDB ID: 6JIJ

Hetero Atom Contents

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Ligands
Code Name Style Show Link
Non-standard Residues
Code Name Show
02J 5-methyl-1,2-oxazole-3-carboxylic acid
PJE (E,4s)-4-azanyl-5-[(3s)-2-oxidanylidenepyrrolidin-3-yl]pent-2-enoic acid
Glycosylation
Code Name Emphasize
Modification
Code Name Show
010 Phenylmethanol

Structure summary

Code : 6JIJ   PDBj   RCSB PDB   PDBe
Header : HYDRALASE/INHIBITOR
Title : The Crystal Structure of Main Protease from Mouse Hepatitis Virus A59 in Complex with an inhibitor
Release Data : 2019-04-24
Compound :
mol_id molecule chains
1 Replicative polyprotein 1ab B,C,A
mol_id molecule chains
2 02J-ALA-VAL-LEU-PJE-010 D,E,F
Source :
mol_id organism_scientific organism_common expression_system
1 Murine coronavirus (strain A59)  (taxid:11142) MHV-A59 Escherichia coli  (taxid:562)
strain: A59
mol_id organism_scientific
2 Synthetic construct  (taxid:32630)
synthetic: yes
Authors : Cui, W., Cui, S.S.
Keywords : Main Protease, Mouse Hepatitis Virus A59, HYDRALASE-INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.65 Å )
Citation :

The crystal structure of main protease from mouse hepatitis virus A59 in complex with an inhibitor.

Cui, W.,Cui, S.,Chen, C.  et al.
(2019)  Biochem. Biophys. Res. Commun.  511 : 794 - 799

PubMed: 30833083
DOI: 10.1016/j.bbrc.2019.02.105

Reaction

Chain : B, C, A
UniProt : Q66WN6 (Q66WN6_9BETC)
Reaction: EC: Evidence:
Physiological Direction:
ATP + H2O = ADP + H(+) + phosphate 3.6.4.12 ARBA:ARBA00001665
-
ATP + H2O = ADP + H(+) + phosphate 3.6.4.13 ARBA:ARBA00001556
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Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal). 3.4.19.12 ARBA:ARBA00000707
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a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'- triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L- homocysteine 2.1.1.56 ARBA:ARBA00034403
left-to-right
a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'- triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA + H(+) + S- adenosyl-L-homocysteine 2.1.1.57 ARBA:ARBA00024256
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a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'- end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + diphosphate 2.7.7.50 ARBA:ARBA00024520
left-to-right
uridylyl-uridylyl-ribonucleotide-RNA = a 3'-end uridylyl- 2',3'-cyclophospho-uridine-RNA + a 5'-end dephospho-ribonucleoside- RNA - ARBA:ARBA00024600
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