Brand  (β version)

PDB ID: 6J8E

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Ligands
Code Name Style Show Link
9Z9 (3beta,14beta,17beta,25r)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en PoSSuM
NA Sodium ion PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
BMA Beta-D-mannopyranose
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
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Structure summary

Code : 6J8E   PDBj   RCSB PDB   PDBe
Header : MEMBRANE PROTEIN/TOXIN
Title : Human Nav1.2-beta2-KIIIA ternary complex
Release Data : 2019-02-27
Compound :
mol_id molecule chains
1 Sodium channel subunit beta-2 C
mol_id molecule chains synonym
2 Sodium channel protein type 2 subunit alpha A HBSC II,Sodium channel protein brain II subunit alpha,Sodium channel protein type II subunit alpha,Voltage-gated sodium channel subunit alpha Nav1.2
mol_id molecule chains
3 Mu-conotoxin KIIIA D
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Homo sapiens  (taxid:9606)
gene: SCN2B, UNQ326/PRO386
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Homo sapiens  (taxid:9606)
gene: SCN2A, NAC2, SCN2A1, SCN2A2
mol_id organism_scientific organism_common
3 Conus kinoshitai  (taxid:376876) Kinoshita's cone
synthetic: yes
Authors : Pan, X., Li, Z., Huang, X., Huang, G., Yan, N.
Keywords : transmembrane protein, MEMBRANE PROTEIN, MEMBRANE PROTEIN-TOXIN complex
Exp. method : ELECTRON MICROSCOPY ( 3.0 Å )
Citation :

Molecular basis for pore blockade of human Na+channel Nav1.2 by the mu-conotoxin KIIIA.

Pan, X.,Li, Z.,Huang, X.  et al.
(2019)  Science  363 : 1309 - 1313

PubMed: 30765605
DOI: 10.1126/science.aaw2999

Reaction

Chain : C
UniProt : O60939 (SCN2B_HUMAN)
Reaction : -
Chain : A
UniProt : Q99250 (SCN2A_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Na(+)(in) = Na(+)(out) - PubMed:1325650, PubMed:17021166, PubMed:28256214, PubMed:29844171
-
Chain : D
UniProt : P0C195 (CM3A_CONKI)
Reaction : -