Brand  (β version)

PDB ID: 6IA1

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Ligands
Code Name Style Show Link
ACT Acetate ion PoSSuM
AR Argon PoSSuM
AZA 8-azaxanthine PoSSuM
NA Sodium ion PoSSuM
PO4 Phosphate ion PoSSuM
Non-standard Residues
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Glycosylation
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Modification
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ACE Acetyl group

Structure summary

Code : 6IA1   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : urate oxidase under 120 bar of argon
Release Data : 2019-12-18
Compound :
mol_id molecule chains synonym
1 Uricase A Urate oxidase
ec: 1.7.3.3
other_details: The 6 last residues SLKSKL are not located in the experimental density. The ACE (acetate) group at the N term is part of the protein, not from expression system
Source :
mol_id organism_scientific expression_system
1 Aspergillus flavus  (taxid:5059) Saccharomyces  (taxid:4930)
gene: uaZ, uox
Authors : Prange, T., Colloc'h, N., Carpentier, P.
Keywords : aspergillus flavus, homotetramer, purine metabolism, argon, high pressure, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.36 Å )
Citation :

Comparative study of the effects of high hydrostatic pressure per se and high argon pressure on urate oxidase ligand stabilization.

Prange, T.,Carpentier, P.,Dhaussy, A.C.  et al.
(2022)  Acta Crystallogr D Struct Biol  78 : 162 - 173

PubMed: 35102882
DOI: 10.1107/S2059798321012134

Protein-noble gas interactions investigated by crystallography on three enzymes - Implication on anesthesia and neuroprotection mechanism.

Colloc'h, N.,Marassio, G.,Prange, T.
(2011)  Current trends in X-ray crystallography  : 285 - 309

Gas-sensitive biological crystals processed in pressurized oxygen and krypton atmospheres: deciphering gas channels in proteins using a novel soak-and-freeze methodology

Lafumat, B.,Mueller-Dieckmann, C.,Leonard, G.  et al.
(2016)  Journal of Applied Crystallography  49 : 1478 - 1482

Reaction

Chain : A
UniProt : Q00511 (URIC_ASPFL)
Reaction: EC: Evidence:
Physiological Direction:
urate + O2 + H2O = 5-hydroxyisourate + H2O2 1.7.3.3 PubMed:1339455, PubMed:17020862, PubMed:25314114, Ref.3
left-to-right PubMed:1339455, PubMed:17020862, Ref.3