Het-PDB Navi2 (PDB: 6I1I)

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Ligands
Code	Name		Style	Show	Link
JPP	Piperacillin (open form)				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 6I1I

Code :

6I1I PDBj RCSB PDB PDBe

Header :

PEPTIDE BINDING PROTEIN

Title :

Crystal structure of TP domain from Escherichia coli penicillin-binding protein 3 in complex with penicillin

Release Data :

2019-11-20

Compound :

mol_id	molecule	chains	synonym
1	Peptidoglycan D,D-transpeptidase FtsI,Peptidoglycan D,D-transpeptidase FtsI	A	Penicillin-binding protein 3,PBP-3,Penicillin-binding protein 3,PBP-3
	ec: 3.4.16.4,3.4.16.4

Source :

mol_id	organism_scientific	expression_system
1	Escherichia coli O157:H7 (taxid:83334)	Escherichia coli BL21(DE3) (taxid:469008)
	gene: ftsI, pbpB, Z0094, ECs0088

Authors :

Bellini, D., Koekemoer, L., Newman, H., Dowson, C.G.

Keywords :

penicillin-binding protein, peptidoglycan, Transpeptidase, PEPTIDE BINDING PROTEIN

Exp. method :

X-RAY DIFFRACTION ( 1.75 Å )

Citation :

Novel and Improved Crystal Structures of H. influenzae, E. coli and P. aeruginosa Penicillin-Binding Protein 3 (PBP3) and N. gonorrhoeae PBP2: Toward a Better Understanding of beta-Lactam Target-Mediated Resistance.

Bellini, D.,Koekemoer, L.,Newman, H. et al.
(2019) J.Mol.Biol. 431 : 3501 - 3519

PubMed: 31301409
DOI: 10.1016/j.jmb.2019.07.010

Chain :

UniProt :

P0AD69 (FTSI_ECO57)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Preferential cleavage: (Ac)2-L-Lys-D-Ala-\|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine.	3.4.16.4	HAMAP- Rule:MF_02080
	-	HAMAP- Rule:MF_02080

PDB ID: 6I1I

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Structure summary

Reaction