Brand  (β version)

PDB ID: 6HXL

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Ligands
Code Name Style Show Link
COA Coenzyme a PoSSuM
FLC Citrate anion PoSSuM
PEG Di(hydroxyethyl)ether PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 6HXL   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : Structure of the citryl-CoA lyase core module of human ATP citrate lyase in complex with citrate and CoASH (space group P21)
Release Data : 2019-04-10
Compound :
mol_id molecule chains synonym
1 ATP-citrate synthase A,B,C,D,E,F,G,H ATP-citrate (pro-S-)-lyase,ACL,Citrate cleavage enzyme
ec: 2.3.3.8
other_details: Before crystallization, the N-terminal sequence MGSSHHHHHHSSGLVPR was removed by thrombin digestion.
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: ACLY
expression_system_plasmid: pET15b
Authors : Verstraete, K., Verschueren, K.
Keywords : ATP citrate lyase, central metabolism, acetyl-Coa, citrate shuttle, rTCA cycle, citryl-CoA, lipogenesis, LYASE
Exp. method : X-RAY DIFFRACTION ( 1.35 Å )
Citation :

Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle.

Verschueren, K.H.G.,Blanchet, C.,Felix, J.  et al.
(2019)  Nature  568 : 571 - 575

PubMed: 30944476
DOI: 10.1038/s41586-019-1095-5

Reaction

Chain : A, B, C, D, E, F, G, H
UniProt : P53396 (ACLY_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
acetyl-CoA + ADP + oxaloacetate + phosphate = ATP + citrate + CoA 2.3.3.8 PubMed:10653665, PubMed:1371749, PubMed:19286649, PubMed:23932781, PubMed:9116495
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