Brand  (β version)

PDB ID: 6HOT

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
CIY (2e)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enal PoSSuM
EDO 1,2-ethanediol PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 6HOT   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Human protein kinase CK2 alpha in complex with ferulic aldehyde
Release Data : 2019-10-02
Compound :
mol_id molecule chains synonym
1 Casein kinase II subunit alpha A CK II alpha
ec: 2.7.11.1
fragment: kinase domain (residues 1-337)
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: CSNK2A1, CK2A1
Authors : Battistutta, R., Lolli, G.
Keywords : kinase domain, transferase
Exp. method : X-RAY DIFFRACTION ( 1.5000 Å )
Citation :

Biochemical and cellular mechanism of protein kinase CK2 inhibition by deceptive curcumin.

Cozza, G.,Zonta, F.,Dalle Vedove, A.  et al.
(2020)  Febs J.  287 : 1850 - 1864

PubMed: 31661600
DOI: 10.1111/febs.15111

Reaction

Chain : A
UniProt : P68400 (CSK21_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) 2.7.11.1 PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:20545769, PubMed:20625391, PubMed:21482717, PubMed:22017874, PubMed:22184066, PubMed:23123191, PubMed:28512243, PubMed:30699359, PubMed:30898438, PubMed:31439799
left-to-right PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:20545769, PubMed:21482717, PubMed:23123191, PubMed:28512243, PubMed:30699359, PubMed:30898438, PubMed:31439799, PubMed:35597237
L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) 2.7.11.1 PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:20625391, PubMed:22325354, PubMed:31439799
left-to-right PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:31439799