Brand  (β version)

PDB ID: 6HLB

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Ligands
Code Name Style Show Link
CA Calcium ion PoSSuM
CL Chloride ion PoSSuM
DMS Dimethyl sulfoxide PoSSuM
NA Sodium ion PoSSuM
PO4 Phosphate ion PoSSuM
Non-standard Residues
Code Name Show
ALN Naphthalen-2-yl-3-alanine
SLL (2s)-2-azanyl-6-[(4-hydroxy-4-oxo-butanoyl)amino]hexanoic acid
Glycosylation
Code Name Emphasize
Modification
Code Name Show
00S 4-(aminomethyl)benzenecarboximidamide

Structure summary

Code : 6HLB   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : X-ray structure of furin in complex with the cyclic peptide C[succinyl-Phe-2-Nal-(Arg)4-Lys]-Arg-4-Amba
Release Data : 2019-02-06
Compound :
mol_id molecule chains synonym
1 Furin A Dibasic-processing enzyme,Paired basic amino acid residue-cleaving enzyme,PACE
ec: 3.4.21.75
mol_id molecule chains
2 PHE-(ALN)-ARG-ARG-ARG-ARG-SLL-ARG-00S B
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Homo sapiens  (taxid:9606)
gene: FURIN, FUR, PACE, PCSK3
expression_system_cell_line: HEK293S
mol_id organism_scientific
2 Synthetic construct  (taxid:32630)
synthetic: yes
Authors : Dahms, S.O.
Keywords : protease proprotein convertase inhibitor complex cyclic peptide, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.000 Å )
Citation :

Design, Synthesis, and Characterization of Macrocyclic Inhibitors of the Proprotein Convertase Furin.

Van Lam van, T.,Ivanova, T.,Hardes, K.  et al.
(2019)  Chemmedchem  14 : 673 - 685

PubMed: 30680958
DOI: 10.1002/cmdc.201800807

Reaction

Chain : A
UniProt : P09958 (FURIN_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg-|-Zaa- bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors. 3.4.21.75 PubMed:11799113, PubMed:1438214, PubMed:1629222, PubMed:1644824, PubMed:1713771, PubMed:2251280, PubMed:24666235, PubMed:25974265, PubMed:31091448, PubMed:32362314, PubMed:32703818, PubMed:7592877, PubMed:7690548, PubMed:7737999, PubMed:8253774, PubMed:9130696
-
Cofactor: Evidence: Note:
Ca(2+) ECO:0000269 | PubMed:1644824
ECO:0000269 | PubMed:24666235
ECO:0000269 | PubMed:25974265
ECO:0000269 | PubMed:9130696
Binds 3 calcium ions per subunit.