Het-PDB Navi2 (PDB: 6HL1)

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Ligands
Code	Name		Style	Show	Link
JN3	Chenodeoxycholic acid				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 6HL1

Code :

6HL1 PDBj RCSB PDB PDBe

Header :

NUCLEAR PROTEIN

Title :

Crystal Structure of Farnesoid X receptor (FXR) with bound NCoA-2 peptide and CDCA

Release Data :

2019-05-29

Compound :

mol_id	molecule	chains	synonym
1	Bile acid receptor	A	Farnesoid X-activated receptor,Farnesol receptor HRR-1,Nuclear receptor subfamily 1 group H member 4,Retinoid X receptor-interacting protein 14,RXR-interacting protein 14
	other_details: Protein Domain with bound CDCA

mol_id	molecule	chains
2	NCoA-2 peptide (Nuclear receptor coactivator 2), LYS-GLU-ASN-ALA-LEU-LEU-ARG-TYR-LEU-LEU-ASP-LYS-ASP	B

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli BL21(DE3) (taxid:469008)
	gene: NR1H4, BAR, FXR, HRR1, RIP14

mol_id	organism_scientific	organism_common
2	Homo sapiens (taxid:9606)	Human
	synthetic: yes

Authors :

Kudlinzki, D., Merk, D., Linhard, V.L., Saxena, K., Schubert-Zsilavecz, M., Schwalbe, H.

Keywords :

Activator, DNA-binding, Receptor, Repressor, Complex, NUCLEAR PROTEIN

Exp. method :

X-RAY DIFFRACTION ( 1.599 Å )

Citation :

Molecular tuning of farnesoid X receptor partial agonism.

Merk, D.,Sreeramulu, S.,Kudlinzki, D. et al.
(2019) Nat Commun 10 : 2915 - 2915

PDB ID: 6HL1