Het-PDB Navi2 (PDB: 6HEY)

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Ligands
Code	Name		Style	Show	Link
FZW	3-[(4,6-dipyridin-3-yl-1,3,5-triazin-2-yl)amino]-4-methyl-~{N}-[3-(trifluoromethyl)phenyl]benzamide				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 6HEY

Code :

6HEY PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with the NVP-BHG712 derivative ATNK002

Release Data :

2019-08-28

Compound :

mol_id	molecule	chains	synonym
1	Ephrin type-A receptor 2	A	Epithelial cell kinase,Tyrosine-protein kinase receptor ECK
	ec: 2.7.10.1

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: EPHA2, ECK

Authors :

Kudlinzki, D., Troester, A., Witt, K., Linhard, V.L., Gande, S.L., Saxena, K., Schwalbe, H.

Keywords :

Inhibitor, Complex, Protein Tyrosine Kinase, Transferase

Exp. method :

X-RAY DIFFRACTION ( 1.367 Å )

Citation :

Effects of NVP-BHG712 chemical modifications on EPHA2 binding and affinity

Troester, A.,Kudlinzki, D.,Saxena, K. et al.
To Be Published

Chain :

UniProt :

P29317 (EPHA2_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]	2.7.10.1	PROSITE-ProRule:PRU10028, PubMed:2174105
	-	PROSITE-ProRule:PRU10028, PubMed:2174105

PDB ID: 6HEY