Brand  (β version)

PDB ID: 6HDP

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Ligands
Code Name Style Show Link
FZ5 Scorzodihydrostilbene a PoSSuM
NA Sodium ion PoSSuM
Non-standard Residues
Code Name Show
PTR O-phosphotyrosine
SEP Phosphoserine
Glycosylation
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Modification
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Structure summary

Code : 6HDP   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Human DYRK2 bound to Scorzodihydrostilbene A
Release Data : 2019-08-28
Compound :
mol_id molecule chains
1 Dual specificity tyrosine-phosphorylation-regulated kinase 2 A
ec: 2.7.12.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: DYRK2
expression_system_cell_line: BL21(DE3)
expression_system_plasmid: pNIC28-Bsa4
Authors : Elkins, J.M., Soundararajan, M., Proksch, P., Meijer, L., Vollmar, M., Krojer, T., Bountra, C., Edwards, A.M., Arrowsmith, C., Knapp, S.
Keywords : Kinase, Structural Genomics Consortium, SGC, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.30 Å )
Citation :

DYRK2 bound to Scorzodihydrostilbene A

Elkins, J.M.,Knapp, S.
To Be Published 

Reaction

Chain : A
UniProt : Q92630 (DYRK2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) 2.7.12.1 PubMed:22998443
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L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) 2.7.12.1 PubMed:22998443
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L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+) 2.7.12.1 PubMed:22998443
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Cofactor: Evidence: Note:
Mg(2+) ECO:0000269 | PubMed:9748265
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Mn(2+) ECO:0000269 | PubMed:9748265
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