Het-PDB Navi2 (PDB: 6HD4)

The number of atoms exceeds 100,000.
So, it can not be displayed here.

Select unit:

Select hetatm:

information

centroid:

interaction residue:

Select chain: Sequence Hide other chain(s)

Data format:

Color scheme of protein:

Ligands
Code	Name	Link
GOL	Glycerol	PoSSuM
CL	Chloride ion	PoSSuM
FYW	6-[(3~{R})-3-oxidanylpyrrolidin-1-yl]-5-pyrimidin-5-yl-~{N}-[4-(trifluoromethyloxy)phenyl]pyridine-3-carboxamide	PoSSuM
STI	4-(4-methyl-piperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide	PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 6HD4

Code :

6HD4 PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

ABL1 IN COMPLEX WITH COMPOUND 7 AND IMATINIB (STI-571)

Release Data :

2018-10-24

Compound :

mol_id	molecule	chains	synonym
1	Tyrosine-protein kinase ABL1	A,B	Abelson murine leukemia viral oncogene homolog 1,Abelson tyrosine-protein kinase 1,Proto-oncogene c-Abl,p150
	ec: 2.7.10.2 fragment: KINASE DOMAIN other_details: The electron density for the region A294-A297 is poor and a good fit could not be found

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Mus musculus (taxid:10090)	Mouse	Baculovirus expression vector pFastBac1-HM (taxid:274590)
	gene: Abl1, Abl

Authors :

Cowan-Jacob, S.W.

Keywords :

PHOSPHOTRANSFERASE, Inhibitor complex, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 2.03 Å )

Citation :

Discovery of Asciminib (ABL001), an Allosteric Inhibitor of the Tyrosine Kinase Activity of BCR-ABL1.

Schoepfer, J.,Jahnke, W.,Berellini, G. et al.
(2018) J. Med. Chem. 61 : 8120 - 8135

Chain :

A, B

UniProt :

P00520 (ABL1_MOUSE)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]	2.7.10.2	PROSITE-ProRule:PRU10028, PubMed:10988075, PubMed:12748290, PubMed:19878872, PubMed:20072125
	-

PDB ID: 6HD4