Brand  (β version)

PDB ID: 6HCU

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Ligands
Code Name Style Show Link
FYB ~{N}-[[4,4-bis(fluoranyl)-1-oxidanyl-cyclohexyl]methyl]-6-fluoranyl-4-oxidanylidene-chromene-2-carboxamide PoSSuM
HIS Histidine PoSSuM
LYS Lysine PoSSuM
PEG Di(hydroxyethyl)ether PoSSuM
TRS 2-amino-2-hydroxymethyl-propane-1,3-diol PoSSuM
Non-standard Residues
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Structure summary

Code : 6HCU   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal Structure of Lysyl-tRNA Synthetase from Plasmodium falciparum bound to a difluoro cyclohexyl chromone ligand
Release Data : 2019-04-03
Compound :
mol_id molecule chains synonym
1 Lysine--tRNA ligase A,B Lysyl-tRNA synthetase
ec: 6.1.1.6
Source :
mol_id organism_scientific expression_system
1 Plasmodium falciparum 3D7  (taxid:36329) Escherichia coli  (taxid:562)
gene: PF3D7_1350100
Authors : Tamjar, J., Robinson, D.A., Baragana, B., Norcross, N., Forte, B., Walpole, C., Gilbert, I.H.
Keywords : ADENYLYLTRANSFERASE ACTIVITY, TRNA BINDING, LIGASE, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.6200 Å )
Citation :

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.

Baragana, B.,Forte, B.,Choi, R.  et al.
(2019)  Proc.Natl.Acad.Sci.USA  116 : 7015 - 7020

PubMed: 30894487
DOI: 10.1073/pnas.1814685116

Reaction

Chain : A, B
UniProt : Q8IDJ8 (Q8IDJ8_PLAF7)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl- tRNA(Lys) 6.1.1.6 ARBA:ARBA00000204, RuleBase:RU003748
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