Het-PDB Navi2 (PDB: 6HCA)

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Ligands
Code	Name	Link
CL	Chloride ion	PoSSuM
FXW	6,6'-(ethane-1,2-diyl)bis(4-cyclopropyl-3,4-dihydro-2h-1,2,4-benzothiadiazine 1,1-dioxide)	PoSSuM
GOL	Glycerol	PoSSuM
PEG	Di(hydroxyethyl)ether	PoSSuM
SO4	Sulfate ion	PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 6HCA

Code :

6HCA PDBj RCSB PDB PDBe

Header :

MEMBRANE PROTEIN

Title :

STRUCTURE OF GLUA2 LIGAND-BINDING DOMAIN (S1S1J) IN COMPLEX WITH POSITIVE ALLOSTERIC MODULATOR TDPAM02 AT 1.8 A RESOLUTION

Release Data :

2019-04-03

Compound :

mol_id	molecule	chains	synonym
1	Glutamate receptor 2,Glutamate receptor 2	A,B	GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2,GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2
	other_details: NATIVE GLUA2 IS A MEMBRANE PROTEIN. THE CRYSTALLIZED PROTEIN IS THE LIGAND-BINDING DOMAIN OF GLUA2. TRANSMEMBRANE REGIONS ARE REPLACED WITH A GLY-THR LINKER (RESIDUES 118-119) AND GLY1-ALA2 IS A CLONING REMNANT. THE SEQUENCE MATCHES DISCONTINUOUSLY WITH REFERENCE DATABASE (413-527, 653-797).,NATIVE GLUA2 IS A MEMBRANE PROTEIN. THE CRYSTALLIZED PROTEIN IS THE LIGAND-BINDING DOMAIN OF GLUA2. TRANSMEMBRANE REGIONS ARE REPLACED WITH A GLY-THR LINKER (RESIDUES 118-119) AND GLY1-ALA2 IS A CLONING REMNANT. THE SEQUENCE MATCHES DISCONTINUOUSLY WITH REFERENCE DATABASE (413-527, 653-797).

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Rattus norvegicus (taxid:10116)	Rat	Escherichia coli BL21(DE3) (taxid:469008)
	gene: Gria2, Glur2 expression_system_variant: ORIGAMI B expression_system_vector_type: plasmid expression_system_plasmid: PET22B

Authors :

Laulumaa, S., Hansen, K.V., Frydenvang, K., Kastrup, J.S.

Keywords :

GluA2-S1S2J, AMPA receptor, Ligand-binding domain, positive allosteric modulator, membrane protein, signaling protein

Exp. method :

X-RAY DIFFRACTION ( 1.8820 Å )

Citation :

Crystal Structures of Potent Dimeric Positive Allosteric Modulators at the Ligand-Binding Domain of the GluA2 Receptor.

Laulumaa, S.,Hansen, K.V.,Masternak, M. et al.
(2019) Acs Med.Chem.Lett. 10 : 243 - 247

Chain :

A, B

UniProt :

P19491 (GRIA2_RAT)

PDB ID: 6HCA