PDB ID: 6HAY
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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FX8 | (2~{S},4~{R})-~{N}-[[2-[2-[2-[2-[4-[3-azanyl-6-(2-hydroxyphenyl)pyridazin-4-yl]piperazin-1-yl]ethoxy]ethoxy]ethoxy]-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-1-[(2~{S})-2-[(1-fluoranylcyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide | PoSSuM | |||
EDO | 1,2-ethanediol | PoSSuM | |||
FMT | Formic acid | PoSSuM |
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Download interaction data: 6HAY
Structure summary
Code : | 6HAY PDBj RCSB PDB PDBe | ||||||||||||||||||||||||||||||||||||||||||||||||
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Header : | GENE REGULATION | ||||||||||||||||||||||||||||||||||||||||||||||||
Title : | Crystal structure of PROTAC 1 in complex with the bromodomain of human SMARCA2 and pVHL:ElonginC:ElonginB | ||||||||||||||||||||||||||||||||||||||||||||||||
Release Data : | 2019-06-12 | ||||||||||||||||||||||||||||||||||||||||||||||||
Compound : |
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Source : |
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Authors : | Roy, M., Bader, G., Diers, E., Trainor, N., Farnaby, W., Ciulli, A. | ||||||||||||||||||||||||||||||||||||||||||||||||
Keywords : | bromodomain, E3 Ubiquitin Protein Ligase, GENE REGULATION | ||||||||||||||||||||||||||||||||||||||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.2400 Å ) | ||||||||||||||||||||||||||||||||||||||||||||||||
Citation : |
BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design.
Farnaby, W.,Koegl, M.,Roy, M.J.
et al.
PubMed: 31178587 |
Reaction
Chain : | A, E |
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UniProt : | P51531 (SMCA2_HUMAN) |
Reaction : | - |
Chain : | B, F |
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UniProt : | P40337 (VHL_HUMAN) |
Reaction : | - |
Chain : | C, G |
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UniProt : | Q15369 (ELOC_HUMAN) |
Reaction : | - |
Chain : | D, H |
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UniProt : | Q15370 (ELOB_HUMAN) |
Reaction : | - |