Brand  (β version)

color scheme of protein:

hetatm:

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information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
NA Sodium ion
2CV Hega-10
FVK ~{N}-[2-[[(2~{S})-2-oxidanyl-3-(4-oxidanylphenoxy)propyl]amino]ethyl]morpholine-4-carboxamide
Code : 6H7N
Header : IMMUNE SYSTEM
Title : ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND PARTIAL AGONIST XAMOTEROL AND NANOBODY Nb6B9
Release Data : 2018-10-17
Compound :
mol_id molecule chains synonym
1 Thioredoxin 1 E,F Trx-1
mutation: C32S,C35S
mol_id molecule chains synonym
2 Beta-1 adrenergic receptor A,B Beta-1 adrenoreceptor,Beta-T
mutation: R68S,M90V,C116L,F327A,F338M,C358A
mol_id molecule chains
3 Camelid antibody fragment Nb6B9 C,D
Source :
mol_id organism_scientific expression_system
1 Escherichia coli (strain K12)  (taxid:83333) Trichoplusia ni  (taxid:7111)
gene: trxA, fipA, tsnC, b3781, JW5856
expression_system_common: Cabbage looper
expression_system_vector_type: Baculovirus
mol_id organism_scientific organism_common expression_system
2 Meleagris gallopavo  (taxid:9103) Turkey Trichoplusia ni  (taxid:7111)
gene: ADRB1
expression_system_common: Cabbage looper
expression_system_vector_type: Baculovirus
mol_id organism_scientific organism_common expression_system
3 Lama glama  (taxid:9844) Llama Escherichia coli  (taxid:562)
Authors : Warne, T., Edwards, P.C., Dore, A.S., Leslie, A.G.W., Tate, C.G.
Keywords : Beta1 Adrenoceptor, Activated, Partial Agonist, Nanobody, immune system
Exp. method : X-RAY DIFFRACTION ( 2.50 Å )
Citation :

Molecular basis for high affinity agonist binding in GPCRs

Warne, T.,Edwards, P.C.,Dore, A.S.  et al.
(2018)  Biorxiv 

DOI: 10.1101/436212

Chain : E, F
UniProt : P0AA25 (THIO_ECOLI)
Reaction : -
Chain : A, B
UniProt : P07700 (ADRB1_MELGA)
Reaction : -