Brand  (β version)

PDB ID: 6H5X

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Ligands
Code Name Style Show Link
ZN Zinc ion PoSSuM
FT8 Omapatrilat PoSSuM
CL Chloride ion PoSSuM
XPE 3,6,9,12,15,18,21,24,27-nonaoxanonacosane-1,29-diol PoSSuM
PG4 Tetraethylene glycol PoSSuM
EDO 1,2-ethanediol PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
FUC Alpha-L-fucopyranose
Modification
Code Name Show

Structure summary

Code : 6H5X   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal structure of human Angiotensin-1 converting enzyme N-domain in complex with Omapatrilat.
Release Data : 2018-11-07
Compound :
mol_id molecule chains synonym
1 Angiotensin-converting enzyme A,B ACE,Dipeptidyl carboxypeptidase I,Kininase II
ec: 3.2.1.-,3.4.15.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Cricetulus griseus  (taxid:10029)
gene: ACE, DCP, DCP1
Authors : Cozier, G.E., Acharya, K.R.
Keywords : Angiotensin-1 converting enzyme, ACE inhibitor, Omapatrilat, Vasopeptidase inhibitor, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.800 Å )
Citation :

Molecular Basis for Multiple Omapatrilat Binding Sites within the ACE C-Domain: Implications for Drug Design.

Cozier, G.E.,Arendse, L.B.,Schwager, S.L.  et al.
(2018)  J. Med. Chem.  61 : 10141 - 10154

PubMed: 30372620
DOI: 10.1021/acs.jmedchem.8b01309

Reaction

Chain : A, B
UniProt : P12821 (ACE_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II. 3.4.15.1 PubMed:10913258, PubMed:11076943, PubMed:12542396, PubMed:1320019, PubMed:20826823, PubMed:2558109, PubMed:4322742, PubMed:7961923
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angiotensin I + H2O = angiotensin II + L-histidyl-L-leucine 3.4.15.1 PubMed:11432860, PubMed:1851160, PubMed:19773553, PubMed:23056909, PubMed:4322742, PubMed:6270633
left-to-right
bradykinin + H2O = bradykinin(1-7) + L-Phe-L-Arg - PubMed:4322742, PubMed:6055465, PubMed:6270633, PubMed:7683654, PubMed:2558109
left-to-right
H2O + substance P = L-Leu-L-Met-NH2 + substance P(1-9) - PubMed:6208535
left-to-right
H2O + substance P = Gly-L-Leu-L-Met-NH2 + substance P(1-8) - PubMed:6208535
left-to-right
H2O + substance P = L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2 + substance P(1-6) - PubMed:6208535
left-to-right
H2O + neurotensin = L-isoleucyl-L-leucine + neurotensin(1-11) - PubMed:6208535
left-to-right
goralatide + H2O = L-lysyl-L-proline + N-acetyl-L-seryl-L- aspartate - PubMed:26403559, PubMed:7876104, PubMed:8257427
left-to-right
H2O + Met-enkephalin = L-phenylalanyl-L-methionine + L- tyrosylglycylglycine - PubMed:6270633, PubMed:656131
left-to-right
H2O + Leu-enkephalin = L-phenylalanyl-L-leucine + L- tyrosylglycylglycine - PubMed:6270633, PubMed:656131
left-to-right
H2O + Met-enkephalin-Arg-Phe = L-arginyl-L-phenylalanine + Met-enkephalin - UniProtKB:P09470
left-to-right
[Isoform Testis-specific]
Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II. 		3.4.15.1 PubMed:1668266
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