Brand  (β version)

PDB ID: 6H40

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Ligands
Code Name Style Show Link
CL Chloride ion PoSSuM
FW5 (2~{S})-3-methoxypropane-1,2-diol PoSSuM
GOL Glycerol PoSSuM
MG Magnesium ion PoSSuM
SAH S-adenosyl-L-homocysteine PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 6H40   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : High resolution structure of MeT1 from Mycobacterium hassiacum in complex with 3-methoxy-1,2-propanediol.
Release Data : 2019-01-16
Compound :
mol_id molecule chains
1 Methyltransferase domain protein A
Source :
mol_id organism_scientific expression_system
1 Mycolicibacterium hassiacum DSM 44199  (taxid:1122247) Escherichia coli BL21(DE3)  (taxid:469008)
gene: C731_4163
Authors : Pereira, P.J.B., Ripoll-Rozada, J.
Keywords : 3-O-methyltransferase, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.053 Å )
Citation :

Biosynthesis of mycobacterial methylmannose polysaccharides requires a unique 1-O-methyltransferase specific for 3-O-methylated mannosides.

Ripoll-Rozada, J.,Costa, M.,Manso, J.A.  et al.
(2019)  Proc. Natl. Acad. Sci. U.S.A.  116 : 835 - 844

PubMed: 30606802
DOI: 10.1073/pnas.1813450116

Reaction

Chain : A
UniProt : K5B7F3 (MET1_MYCHD)
Reaction: EC: Evidence:
Physiological Direction:
3,3'-di-O-methyl-4alpha-mannobiose + S-adenosyl-L-methionine = 1,3,3'-tri-O-methyl-4alpha-mannobiose + S-adenosyl-L-homocysteine + H(+) 2.1.1.365 PubMed:30606802
left-to-right
Cofactor: Evidence: Note:
Mg(2+) ECO:0000269 | PubMed:30606802
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