Brand  (β version)

PDB ID: 6H3Q

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Ligands
Code Name Style Show Link
FMH 4-[5-(chloromethyl)-1,3-selenazol-2-yl]benzenesulfonamide PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 6H3Q   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : Crystal structure of human carbonic anhydrase II in complex with the 4-(5-(chloromethyl)-1,3-selenazol-2-yl)benzenesulfonamide
Release Data : 2019-07-17
Compound :
mol_id molecule chains synonym
1 Carbonic anhydrase 2 A Carbonate dehydratase II,Carbonic anhydrase C,CAC,Carbonic anhydrase II,CA-II
ec: 4.2.1.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21  (taxid:511693)
gene: CA2
Authors : Ferraroni, M., Angeli, A., Supuran, C.
Keywords : LYASE
Exp. method : X-RAY DIFFRACTION ( 1.3100 Å )
Citation :

Discovery of new 2, 5-disubstituted 1,3-selenazoles as selective human carbonic anhydrase IX inhibitors with potent anti-tumor activity.

Angeli, A.,Trallori, E.,Ferraroni, M.  et al.
(2018)  Eur.J.Med.Chem.  157 : 1214 - 1222

PubMed: 30193219
DOI: 10.1016/j.ejmech.2018.08.096

Reaction

Chain : A
UniProt : P00918 (CAH2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
H(+) + hydrogencarbonate = CO2 + H2O 4.2.1.1 PubMed:11327835, PubMed:11802772, PubMed:11831900, PubMed:12056894, PubMed:12171926, PubMed:1336460, PubMed:14736236, PubMed:15300855, PubMed:15453828, PubMed:15667203, PubMed:15865431, PubMed:16106378, PubMed:16214338, PubMed:16290146, PubMed:16686544, PubMed:16759856, PubMed:16807956, PubMed:17127057, PubMed:17251017, PubMed:17314045, PubMed:17330962, PubMed:17346964, PubMed:17540563, PubMed:17588751, PubMed:17705204, PubMed:18024029, PubMed:18162396, PubMed:18266323, PubMed:18374572, PubMed:18481843, PubMed:18618712, PubMed:18640037, PubMed:18942852, PubMed:1909891, PubMed:1910042, PubMed:19170619, PubMed:19186056, PubMed:19206230, PubMed:19520834, PubMed:19778001, PubMed:7761440, PubMed:7901850, PubMed:8218160, PubMed:8262987, PubMed:8399159, PubMed:8451242, PubMed:8485129, PubMed:8639494, PubMed:9265618, PubMed:9398308
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urea = cyanamide + H2O 4.2.1.69 PubMed:10550681, PubMed:11015219
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