PDB ID: 6H3K
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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7PE | 2-(2-(2-(2-(2-(2-ethoxyethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethanol | PoSSuM | |||
FMW | ~{N}8-(2,2-dimethylpropyl)-~{N}2-[2-ethoxy-4-(4-methyl-1,2,4-triazol-3-yl)phenyl]-6-methyl-pyrido[3,4-D]pyrimidine-2,8-diamine | PoSSuM |
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Download interaction data: 6H3K
Structure summary
Code : | 6H3K PDBj RCSB PDB PDBe | ||||||||||||
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Header : | TRANSFERASE | ||||||||||||
Title : | Introduction of a methyl group curbs metabolism of pyrido[3,4-D]pyrimidine MPS1 inhibitors and enables the discovery of the Phase 1 clinical candidate BOS172722. | ||||||||||||
Release Data : | 2018-09-19 | ||||||||||||
Compound : |
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Authors : | Woodward, H.L., Hoelder, S. | ||||||||||||
Keywords : | Kinase, Spindle assembly checkpoint, mitosis, transferase | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.4800 Å ) | ||||||||||||
Citation : |
Introduction of a Methyl Group Curbs Metabolism of Pyrido[3,4- d]pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate N2-(2-Ethoxy-4-(4-methyl-4 H-1,2,4-triazol-3-yl)phenyl)-6-methyl- N8-neopentylpyrido[3,4- d]pyrimidine-2,8-diamine (BOS172722).
Woodward, H.L.,Innocenti, P.,Cheung, K.J.
et al.
PubMed: 30199249 |
Reaction
Chain : | A | ||||||||||||||||
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UniProt : | P33981 (TTK_HUMAN) | ||||||||||||||||
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