Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
FKK 4-[4-[(4-fluorophenyl)methyl]piperazin-1-yl]carbonylbenzenesulfonamide
GOL Glycerol
ZN Zinc ion
Code : 6H34
Header : LYASE
Title : The crystal structure of human carbonic anhydrase II in complex with 4-[(4-fluorophenyl)methyl]-1-piperazinyl]benzenesulfonamide.
Release Data : 2018-12-19
Compound :
mol_id molecule chains synonym
1 Carbonic anhydrase 2 A Carbonate dehydratase II,Carbonic anhydrase C,CAC,Carbonic anhydrase II,CA-II
ec: 4.2.1.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: CA2
Authors : Buemi, M.R., Di Fiore, A., De Luca, L., Ferro, S., Mancuso, F., Monti, S.M., Buonanno, M., Angeli, A., Russo, E., De Sarro, G., Supuran, C.T., De Simone, G., Gitto, R.
Keywords : Protein-inhibitor binding, benzenesulfonamide, LYASE
Exp. method : X-RAY DIFFRACTION ( 1.55 Å )
Citation :

Exploring structural properties of potent human carbonic anhydrase inhibitors bearing a 4-(cycloalkylamino-1-carbonyl)benzenesulfonamide moiety.

Buemi, M.R.,Di Fiore, A.,De Luca, L.  et al.
(2018)  Eur J Med Chem  163 : 443 - 452

PubMed: 30530195
DOI: 10.1016/j.ejmech.2018.11.073

Chain : A
UniProt : P00918 (CAH2_HUMAN)
Reaction : H(2)CO(3) = CO(2) + H(2)O.