Brand  (β version)

PDB ID: 6H22

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Ligands
Code Name Style Show Link
FL5 12-(dimethylamino)-3,10-diethyl-N,N,N-trimethyl-3,10-dihydrodibenzo[3,4:7,8]cycloocta[1,2-D:5,6-D']bis([1,2,3]triazole)-5-aminium PoSSuM
Non-standard Residues
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Glycosylation
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ACE Acetyl group
NH2 Amino group

Structure summary

Code : 6H22   PDBj   RCSB PDB   PDBe
Header : LIGASE
Title : Crystal structure of Mdm2 bound to a stapled peptide
Release Data : 2019-07-31
Compound :
mol_id molecule chains synonym
1 E3 ubiquitin-protein ligase Mdm2 A,B Double minute 2 protein,Hdm2,Oncoprotein Mdm2,RING-type E3 ubiquitin transferase Mdm2,p53-binding protein Mdm2
ec: 2.3.2.27
mutation: E69AK70A
mol_id molecule chains
2 Stapled peptide C,D
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: MDM2
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
synthetic: yes
Authors : Wang, X., Sharma, K., Spring, D.R., Hyvonen, M.
Keywords : Stapled peptide, Inhibitor, E3-ligase, LIGASE
Exp. method : X-RAY DIFFRACTION ( 2.006 Å )
Citation :

Water-soluble, stable and azide-reactive strained dialkynes for biocompatible double strain-promoted click chemistry.

Sharma, K.,Strizhak, A.V.,Fowler, E.  et al.
(2019)  Org.Biomol.Chem.  17 : 8014 - 8018

PubMed: 31418442
DOI: 10.1039/c9ob01745c

Reaction

Chain : A, B
UniProt : Q00987 (MDM2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. 2.3.2.27 PubMed:12821780
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