Brand  (β version)

PDB ID: 6GZY

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Ligands
Code Name Style Show Link
FHH Methyl 4-[(2-oxidanylidene-1,5,6,7-tetrahydrocyclopenta[B]pyridin-3-yl)carbonylamino]butanoate PoSSuM
ZN Zinc ion PoSSuM
SO4 Sulfate ion PoSSuM
EDO 1,2-ethanediol PoSSuM
PGE Triethylene glycol PoSSuM
NA Sodium ion PoSSuM
Non-standard Residues
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Structure summary

Code : 6GZY   PDBj   RCSB PDB   PDBe
Header : LIGASE
Title : HOIP-fragment5 complex
Release Data : 2019-01-30
Compound :
mol_id molecule chains synonym
1 E3 ubiquitin-protein ligase RNF31 A,B HOIL-1-interacting protein,HOIP,RING finger protein 31,RING-type E3 ubiquitin transferase RNF31,Zinc in-between-RING-finger ubiquitin-associated domain protein
ec: 2.3.2.27
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: RNF31, ZIBRA
Authors : Johansson, H., Tsai, Y.C.I., Fantom, K., Chung, C.W., Martino, L., House, D., Rittinger, K.
Keywords : Ubiquitin ligase, E3, inhibitor complex, LIGASE
Exp. method : X-RAY DIFFRACTION ( 2.150 Å )
Citation :

Fragment-Based Covalent Ligand Screening Enables Rapid Discovery of Inhibitors for the RBR E3 Ubiquitin Ligase HOIP.

Johansson, H.,Isabella Tsai, Y.C.,Fantom, K.  et al.
(2019)  J. Am. Chem. Soc.  141 : 2703 - 2712

PubMed: 30657686
DOI: 10.1021/jacs.8b13193

Reaction

Chain : A, B
UniProt : Q96EP0 (RNF31_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine. 2.3.2.31 PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:28481331
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