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Ligands
Code Name Style Show Link
FGE ~{N}-[4-methyl-5-(1-oxidanylidene-7-sulfamoyl-isoindol-5-yl)-1,3-thiazol-2-yl]ethanamide
Non-standard Residues
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Glycosylation
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Code : 6GY0   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : mPI3Kd IN COMPLEX WITH AZ3
Release Data : 2019-02-06
Compound :
mol_id molecule chains synonym
1 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform A PtdIns-3-kinase subunit delta,Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta,p110delta
ec: 2.7.1.153
Source :
mol_id organism_scientific organism_common expression_system
1 Mus musculus  (taxid:10090) Mouse Spodoptera aff. frugiperda 2 RZ-2014  (taxid:1491790)
gene: Pik3cd
Authors : Petersen, J.
Keywords : Inhibitor, PI3K, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.55 Å )
Citation :

A class of highly selective inhibitors bind to an active state of PI3K gamma.

Gangadhara, G.,Dahl, G.,Bohnacker, T.  et al.
(2019)  Nat.Chem.Biol.  15 : 348 - 357

PubMed: 30718815
DOI: 10.1038/s41589-018-0215-0

Chain : A
UniProt : O35904 (PK3CD_MOUSE)
Reaction: EC: Evidence:
Physiological Direction:
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5- bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol-3,4,5-trisphosphate) + ADP + H(+) 2.7.1.153 UniProtKB:O00329
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a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+) 2.7.1.137 UniProtKB:O00329
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1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero- 3-phospho-1D-myo-inositol 4,5-bisphosphate + ATP = 1-octadecanoyl-2- (5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo- inositol 3,4,5-triphosphate) + ADP + H(+) - UniProtKB:O00329
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