Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
K Potassium ion
ZN Zinc ion
DMF Dimethylformamide
FF2 4-chloranyl-~{N}-oxidanyl-1-benzothiophene-2-carboxamide
GOL Glycerol
Code : 6GX3
Header : HYDROLASE
Title : Crystal structure of Schistosoma mansoni HDAC8 complexed with an hydroxamate 1
Release Data : 2018-08-15
Compound :
mol_id molecule chains
1 Histone deacetylase A,B,C,D
ec: 3.5.1.98
Source :
mol_id organism_scientific organism_common expression_system
1 Schistosoma mansoni  (taxid:6183) Blood fluke Escherichia coli  (taxid:562)
gene: HDAC8
Authors : Shaik, T.B., Marek, M., Romier, C.
Keywords : Epigenetics, Histone deacetylase, HDAC8, Selective inhibitor, Pathogen, hydrolase
Exp. method : X-RAY DIFFRACTION ( 2.100 Å )
Citation :

Synthesis, Crystallization Studies, and in vitro Characterization of Cinnamic Acid Derivatives as SmHDAC8 Inhibitors for the Treatment of Schistosomiasis.

Bayer, T.,Chakrabarti, A.,Lancelot, J.  et al.
(2018)  ChemMedChem  13 : 1517 - 1529

PubMed: 29806110
DOI: 10.1002/cmdc.201800238

Chain : A, B, C, D
UniProt : A5H660 (No found in current UniProtKB/SwissProt)
Reaction : -