PDB ID: 6GWR
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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EDO | 1,2-ethanediol | PoSSuM | |||
FEW | 3-(2-imidazo[1,2-a]pyrazin-3-ylethynyl)-~{N}-[3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]-4-propan-2-yl-benzamide | PoSSuM | |||
SO4 | Sulfate ion | PoSSuM |
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Download interaction data: 6GWR
Structure summary
Code : | 6GWR PDBj RCSB PDB PDBe | ||||||||||||
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Header : | TRANSFERASE | ||||||||||||
Title : | Structure of the kinase domain of human DDR1 in complex with a potent and selective inhibitor of DDR1 and DDR2 | ||||||||||||
Release Data : | 2018-08-08 | ||||||||||||
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Authors : | Pinkas, D.M., Fox, A.E., Kupinska, K., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.N. | ||||||||||||
Keywords : | transferase | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.070 Å ) | ||||||||||||
Citation : |
Design, Synthesis, and Biological Evaluation of 3-(Imidazo[1,2- a]pyrazin-3-ylethynyl)-4-isopropyl- N-(3-((4-methylpiperazin-1-yl)methyl)-5-(trifluoromethyl)phenyl)benzamide as a Dual Inhibitor of Discoidin Domain Receptors 1 and 2.
Wang, Z.,Zhang, Y.,Pinkas, D.M.
et al.
PubMed: 30075624 |
Reaction
Chain : | A, B | ||||||||
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UniProt : | Q08345 (DDR1_HUMAN) | ||||||||
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