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Ligands
Code Name Style Show Link
EDO 1,2-ethanediol
FEW 3-(2-imidazo[1,2-a]pyrazin-3-ylethynyl)-~{N}-[3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]-4-propan-2-yl-benzamide
SO4 Sulfate ion
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Code : 6GWR   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Structure of the kinase domain of human DDR1 in complex with a potent and selective inhibitor of DDR1 and DDR2
Release Data : 2018-08-08
Compound :
mol_id molecule chains synonym
1 Epithelial discoidin domain-containing receptor 1 A,B Epithelial discoidin domain receptor 1,CD167 antigen-like family member A,Cell adhesion kinase,Discoidin receptor tyrosine kinase,HGK2,Mammary carcinoma kinase 10,MCK-10,Protein-tyrosine kinase 3A,Protein-tyrosine kinase RTK-6,TRK E,Tyrosine kinase DDR,Tyrosine-protein kinase CAK
ec: 2.7.10.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: DDR1, CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE
Authors : Pinkas, D.M., Fox, A.E., Kupinska, K., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.N.
Keywords : transferase
Exp. method : X-RAY DIFFRACTION ( 2.070 Å )
Citation :

Design, Synthesis, and Biological Evaluation of 3-(Imidazo[1,2- a]pyrazin-3-ylethynyl)-4-isopropyl- N-(3-((4-methylpiperazin-1-yl)methyl)-5-(trifluoromethyl)phenyl)benzamide as a Dual Inhibitor of Discoidin Domain Receptors 1 and 2.

Wang, Z.,Zhang, Y.,Pinkas, D.M.  et al.
(2018)  J. Med. Chem.  61 : 7977 - 7990

PubMed: 30075624
DOI: 10.1021/acs.jmedchem.8b01045

Chain : A, B
UniProt : Q08345 (DDR1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.10.1 PROSITE-ProRule:PRU10028
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