Het-PDB Navi2 (PDB: 6GWG)

The number of atoms exceeds 100,000.
So, it can not be displayed here.

Select unit:

Select hetatm:

information

centroid:

interaction residue:

Select chain: Sequence Hide other chain(s)

Data format:

Color scheme of protein:

Ligands
Code	Name	Link
FEK	(1~{S},2~{S},3~{S})-3-fluoranyl-6-(hydroxymethyl)cyclohex-5-ene-1,2,4-triol	PoSSuM
GOL	Glycerol	PoSSuM
MG	Magnesium ion	PoSSuM
SO4	Sulfate ion	PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 6GWG

Code :

6GWG PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Alpha-galactosidase from Thermotoga maritima in complex with cyclohexene-based carbasugar mimic of galactose covalently linked to the nucleophile

Release Data :

2018-08-22

Compound :

mol_id	molecule	chains	synonym
1	Alpha-galactosidase	A	Melibiase
	ec: 3.2.1.22 other_details: The electron density at the N- and C-terminus was disordered and the residues could not be modelled.

Source :

mol_id	organism_scientific	expression_system
1	Thermotoga maritima MSB8 (taxid:243274)	Escherichia coli 'BL21-Gold(DE3)pLysS AG' (taxid:866768)
	strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099 gene: galA, TM_1192, Tmari_1199

Authors :

Gloster, T.M., Oehler, V.

Keywords :

glycoside hydrolase, galactosidase, carbohydrate processing enzyme, inhibitor, HYDROLASE

Exp. method :

X-RAY DIFFRACTION ( 1.77 Å )

Citation :

Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level.

Ren, W.,Pengelly, R.,Farren-Dai, M. et al.
(2018) Nat Commun 9 : 3243 - 3243

Chain :

UniProt :

G4FEF4 (AGAL_THEMA)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.	3.2.1.22	PubMed:17323919, PubMed:24237145, PubMed:25486100, PubMed:26005928, PubMed:27783466, PubMed:9741105
	-

PDB ID: 6GWG