Het-PDB Navi2 (PDB: 6GVA)

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Ligands
Code	Name	Link
BR	Bromide ion	PoSSuM
CL	Chloride ion	PoSSuM
EDO	1,2-ethanediol	PoSSuM
FCQ	5-(2-azanylethylsulfanyl)-3-propan-2-yl-~{N}-[(4-pyridin-2-ylphenyl)methyl]-2~{H}-pyrazolo[4,3-D]pyrimidin-7-amine	PoSSuM
PG4	Tetraethylene glycol	PoSSuM
PGE	Triethylene glycol	PoSSuM
SGM	Monothioglycerol	PoSSuM

Non-standard Residues
Code	Name	Show
TPO	Phosphothreonine

Glycosylation
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Modification
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Download interaction data: 6GVA

Code :

6GVA PDBj RCSB PDB PDBe

Header :

CELL CYCLE

Title :

CDK2/cyclin A2 in complex with pyrazolo[4,3-D]pyrimidine inhibitor LGR4455

Release Data :

2019-05-01

Compound :

mol_id	molecule	chains	synonym
1	Cyclin-dependent kinase 2	A	Cell division protein kinase 2,p33 protein kinase
	ec: 2.7.11.22

mol_id	molecule	chains	synonym
2	Cyclin-A2	B	Cyclin-A,Cyclin A

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: CDK2, CDKN2

mol_id	organism_scientific	organism_common	expression_system
2	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: CCNA2, CCN1, CCNA

Authors :

Skerlova, J., Rezacova, P.

Keywords :

cyclin-dependent kinase, pyrazolo[4, 3-d]pyrimidine, CELL CYCLE

Exp. method :

X-RAY DIFFRACTION ( 2.1500 Å )

Citation :

3,5,7-Substituted Pyrazolo[4,3- d]pyrimidine Inhibitors of Cyclin-Dependent Kinases and Their Evaluation in Lymphoma Models.

Jorda, R.,Havlicek, L.,Sturc, A. et al.
(2019) J.Med.Chem. 62 : 4606 - 4623

Chain :

UniProt :

P24941 (CDK2_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)	2.7.11.22	PubMed:1396589, PubMed:24670654, PubMed:28216226, PubMed:28666995, PubMed:9030781
	-
L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)	2.7.11.22	PubMed:1396589, PubMed:24670654, PubMed:28666995, PubMed:9030781
	-
Cofactor:	Evidence:	Note:
Mg(2+)	ECO:0000269 \| PubMed:21565702	Binds 2 Mg(2+) ions.

PDB ID: 6GVA