Brand  (β version)

PDB ID: 6GUH

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
EDO 1,2-ethanediol PoSSuM
FB8 4-(2-methyl-3-propan-2-yl-imidazol-4-yl)-~{N}-(4-methylsulfonylphenyl)pyrimidin-2-amine PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 6GUH   PDBj   RCSB PDB   PDBe
Header : CELL CYCLE
Title : CDK2 in complex with AZD5438
Release Data : 2018-12-05
Compound :
mol_id molecule chains synonym
1 Cyclin-dependent kinase 2 A Cell division protein kinase 2,p33 protein kinase
ec: 2.7.11.22
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: CDK2, CDKN2
expression_system_plasmid: pGEX6P1
Authors : Wood, D.J., Korolchuk, S., Tatum, N.J., Wang, L.Z., Endicott, J.A., Noble, M.E.M., Martin, M.P.
Keywords : CDK2, INHIBITOR, CELL CYCLE
Exp. method : X-RAY DIFFRACTION ( 1.50 Å )
Citation :

Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition.

Wood, D.J.,Korolchuk, S.,Tatum, N.J.  et al.
(2019)  Cell Chem Biol  26 : 121 - 130.e5

PubMed: 30472117
DOI: 10.1016/j.chembiol.2018.10.015

Reaction

Chain : A
UniProt : P24941 (CDK2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.22 PubMed:1396589, PubMed:28666995, PubMed:9030781
-
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.22 PubMed:1396589, PubMed:28666995, PubMed:9030781
-