Brand  (β version)

PDB ID: 6GUE

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Ligands
Code Name Style Show Link
FB8 4-(2-methyl-3-propan-2-yl-imidazol-4-yl)-~{N}-(4-methylsulfonylphenyl)pyrimidin-2-amine PoSSuM
Non-standard Residues
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TPO Phosphothreonine
Glycosylation
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Structure summary

Code : 6GUE   PDBj   RCSB PDB   PDBe
Header : CELL CYCLE
Title : CDK2/CyclinA in complex with AZD5438
Release Data : 2018-12-05
Compound :
mol_id molecule chains synonym
1 Cyclin-dependent kinase 2 A Cell division protein kinase 2,p33 protein kinase
ec: 2.7.11.22
mol_id molecule chains synonym
2 Cyclin-A2 B,D Cyclin-A
mol_id molecule chains synonym
3 Cyclin-dependent kinase 2 C Cell division protein kinase 2,p33 protein kinase
ec: 2.7.11.22
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: CDK2, CDKN2
expression_system_plasmid: pGEX6P1
mol_id organism_scientific organism_common expression_system
2 Bos taurus  (taxid:9913) Cattle Escherichia coli BL21(DE3)  (taxid:469008)
gene: CCNA2
expression_system_plasmid: pET21d
mol_id organism_scientific organism_common expression_system
3 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: CDK2, CDKN2
expression_system_plasmid: pGEX6P1
Authors : Wood, D.J., Korolchuk, S., Tatum, N.J., Wang, L.Z., Endicott, J.A., Noble, M.E.M., Martin, M.P.
Keywords : CDK2, CYCLINA, INHIBITOR, CELL CYCLE
Exp. method : X-RAY DIFFRACTION ( 1.99 Å )
Citation :

Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition.

Wood, D.J.,Korolchuk, S.,Tatum, N.J.  et al.
(2019)  Cell Chem Biol  26 : 121 - 130.e5

PubMed: 30472117
DOI: 10.1016/j.chembiol.2018.10.015

Reaction

Chain : C
UniProt : P24941 (CDK2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) 2.7.11.22 PubMed:1396589, PubMed:24670654, PubMed:28216226, PubMed:28666995, PubMed:9030781
-
L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) 2.7.11.22 PubMed:1396589, PubMed:24670654, PubMed:28666995, PubMed:9030781
-
Cofactor: Evidence: Note:
Mg(2+) ECO:0000269 | PubMed:21565702
Binds 2 Mg(2+) ions.
Chain : B, D
UniProt : P30274 (CCNA2_BOVIN)
Reaction : -