Het-PDB Navi2 (PDB: 6GUB)

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Ligands
Code	Name		Style	Show	Link
F9Z	2-(2-chlorophenyl)-8-[(3~{R},4~{R})-1-methyl-3-oxidanyl-piperidin-4-yl]-5,7-bis(oxidanyl)chromen-4-one				PoSSuM

Non-standard Residues
Code	Name	Show
TPO	Phosphothreonine

Glycosylation
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Modification
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Download interaction data: 6GUB

Code :

6GUB PDBj RCSB PDB PDBe

Header :

CELL CYCLE

Title :

CDK2/CyclinA in complex with Flavopiridol

Release Data :

2018-12-05

Compound :

mol_id	molecule	chains	synonym
1	Cyclin-dependent kinase 2	A,C	Cell division protein kinase 2,p33 protein kinase
	ec: 2.7.11.22

mol_id	molecule	chains	synonym
2	Cyclin-A2	B,D	Cyclin-A

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli BL21(DE3) (taxid:469008)
	gene: CDK2, CDKN2 expression_system_plasmid: pGEX6P1

mol_id	organism_scientific	organism_common	expression_system
2	Bos taurus (taxid:9913)	Bovine	Escherichia coli BL21(DE3) (taxid:469008)
	gene: CCNA2 expression_system_plasmid: pET21d

Authors :

Wood, D.J., Korolchuk, S., Tatum, N.J., Wang, L.Z., Endicott, J.A., Noble, M.E.M., Martin, M.P.

Keywords :

CDK2, CYCLINA, INHIBITOR, CELL CYCLE

Exp. method :

X-RAY DIFFRACTION ( 2.52 Å )

Citation :

Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition.

Wood, D.J.,Korolchuk, S.,Tatum, N.J. et al.
(2019) Cell Chem Biol 26 : 121 - 130.e5

Chain :

A, C

UniProt :

P24941 (CDK2_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)	2.7.11.22	PubMed:1396589, PubMed:24670654, PubMed:28216226, PubMed:28666995, PubMed:9030781
	-
L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)	2.7.11.22	PubMed:1396589, PubMed:24670654, PubMed:28666995, PubMed:9030781
	-
Cofactor:	Evidence:	Note:
Mg(2+)	ECO:0000269 \| PubMed:21565702	Binds 2 Mg(2+) ions.

PDB ID: 6GUB