Brand  (β version)

PDB ID: 6GU4

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Ligands
Code Name Style Show Link
FC8 ~{N}2-[(1~{R},2~{S})-2-azanylcyclohexyl]-~{N}6-(3-chlorophenyl)-9-ethyl-purine-2,6-diamine PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 6GU4   PDBj   RCSB PDB   PDBe
Header : CELL CYCLE
Title : CDK1/CyclinB/Cks2 in complex with CGP74514A
Release Data : 2018-12-05
Compound :
mol_id molecule chains synonym
1 Cyclin-dependent kinase 1 A CDK1,Cell division control protein 2 homolog,Cell division protein kinase 1,p34 protein kinase
ec: 2.7.11.22,2.7.11.23
mol_id molecule chains
2 G2/mitotic-specific cyclin-B1 B
mol_id molecule chains synonym
3 Cyclin-dependent kinases regulatory subunit 2 C CKS-2
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: CDK1, CDC2, CDC28A, CDKN1, P34CDC2
expression_system_common: Fall armyworm
expression_system_cell_line: SF9
expression_system_plasmid: pVL1393
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: CCNB1, CCNB
expression_system_plasmid: pET28A
mol_id organism_scientific organism_common expression_system
3 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: CKS2
Authors : Wood, D.J., Korolchuk, S., Tatum, N.J., Wang, L.Z., Endicott, J.A., Noble, M.E.M., Martin, M.P.
Keywords : CDK1, CYCLINB1, CKS2, INHIBITOR, CELL CYCLE
Exp. method : X-RAY DIFFRACTION ( 2.73 Å )
Citation :

Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition.

Wood, D.J.,Korolchuk, S.,Tatum, N.J.  et al.
(2019)  Cell Chem Biol  26 : 121 - 130.e5

PubMed: 30472117
DOI: 10.1016/j.chembiol.2018.10.015

Reaction

Chain : A
UniProt : P06493 (CDK1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) 2.7.11.22 PubMed:19202191, PubMed:2188730, PubMed:23355470, PubMed:2344612, PubMed:26829474, PubMed:30704899
-
L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) 2.7.11.22 PubMed:23355470, PubMed:26829474, PubMed:30704899
-
[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+) 2.7.11.23 UniProtKB:P11440
-
Chain : B
UniProt : P14635 (CCNB1_HUMAN)
Reaction : -
Chain : C
UniProt : P33552 (CKS2_HUMAN)
Reaction : -