Het-PDB Navi2 (PDB: 6GRP)

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Ligands
Code	Name		Style	Show	Link
F4Z	3,5,6-trichloro-2-pyridinol				PoSSuM
NA	Sodium ion				PoSSuM

Non-standard Residues
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Download interaction data: 6GRP

Code :

6GRP PDBj RCSB PDB PDBe

Header :

TRANSPORT PROTEIN

Title :

Crystal Structure Of Human Transthyretin in complex with 3,5,6-trichloro-2-pyridinol (TC2P)

Release Data :

2018-07-11

Compound :

mol_id	molecule	chains	synonym
1	Transthyretin	A,B	ATTR,Prealbumin,TBPA

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: TTR, PALB

Authors :

Grundstrom, C., Zhang, J., Olofsson, A., Andersson, P.L., Sauer-Eriksson, A.E.

Keywords :

transthyretin, transport protein, thyroxine disrupting chemicals, TDCs, 3, 5, 6-trichloro-2-pyridinol, TC2P

Exp. method :

X-RAY DIFFRACTION ( 1.60 Å )

Citation :

Interspecies Variation between Fish and Human Transthyretins in Their Binding of Thyroid-Disrupting Chemicals.

Zhang, J.,Grundstrom, C.,Brannstrom, K. et al.
(2018) Environ. Sci. Technol. 52 : 11865 - 11874

Structure-Based Virtual Screening Protocol for in Silico Identification of Potential Thyroid Disrupting Chemicals Targeting Transthyretin.

Zhang, J.,Begum, A.,Brannstrom, K. et al.
(2016) Environ. Sci. Technol. 50 : 11984 - 11993

PDB ID: 6GRP