Brand  (β version)

PDB ID: 6GNN

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Ligands
Code Name Style Show Link
F4W 3-(12-oxidanylidene-7-thia-9,11-diazatricyclo[6.4.0.0^{2,6}]dodeca-1(8),2(6),9-trien-10-yl)propanoic acid PoSSuM
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Structure summary

Code : 6GNN   PDBj   RCSB PDB   PDBe
Header : TOXIN
Title : Exoenzyme T from Pseudomonas aeruginosa in complex with human 14-3-3 protein beta, tetrameric crystal form bound to STO1101
Release Data : 2018-09-26
Compound :
mol_id molecule chains synonym
1 14-3-3 protein beta/alpha A Protein 1054,Protein kinase C inhibitor protein 1,KCIP-1
mol_id molecule chains
2 Exoenzyme T C
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: YWHAB
expression_system_vector_type: PLASMID
expression_system_plasmid: pET Duet-1
mol_id organism_scientific expression_system
2 Pseudomonas aeruginosa PAO1  (taxid:208964) Escherichia coli  (taxid:562)
gene: exoT, PA0044
expression_system_vector_type: PLASMID
expression_system_plasmid: pET Duet-1
Authors : Karlberg, T., Pinto, A.F., Hornyak, P., Thorsell, A.G., Nareoja, K., Schuler, H.
Keywords : EXOT, PSEUDOMONAS AERUGINOSA, ADP-RIBOSYLATION, NAD, TOXIN
Exp. method : X-RAY DIFFRACTION ( 3.790 Å )
Citation :

14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface.

Karlberg, T.,Hornyak, P.,Pinto, A.F.  et al.
(2018)  Nat Commun  9 : 3785 - 3785

PubMed: 30224724
DOI: 10.1038/s41467-018-06194-1

Reaction

Chain : A
UniProt : P31946 (1433B_HUMAN)
Reaction : -
Chain : C
UniProt : Q9I788 (EXOT_PSEAE)
Reaction: EC: Evidence:
Physiological Direction:
L-arginyl-[protein] + NAD(+) = N(omega)-(ADP-D-ribosyl)-L- arginyl-[protein] + nicotinamide + H(+) 2.4.2.31 PubMed:11298647, PubMed:12807879
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