Brand  (β version)

PDB ID: 6GN1

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Ligands
Code Name Style Show Link
CL Chloride ion PoSSuM
F4N ~{N}-[(~{E})-(6-bromanylimidazo[1,2-a]pyridin-3-yl)methylideneamino]-~{N},2-dimethyl-5-nitro-benzenesulfonamide PoSSuM
Non-standard Residues
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PTR O-phosphotyrosine
Glycosylation
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Modification
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Structure summary

Code : 6GN1   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal Structure of Glycogen synthase kinase-3 beta (GSK3B) in Complex with PIK-75
Release Data : 2018-06-20
Compound :
mol_id molecule chains synonym
1 Glycogen synthase kinase-3 beta B,A GSK-3 beta,Serine/threonine-protein kinase GSK3B
ec: 2.7.11.26,2.7.11.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: GSK3B
Authors : Tesch, R., Becker, C., Mueller, M.P., Sant'Anna, C.M.R., Fraga, C.A.M., Rauh, D.
Keywords : Glycogen synthase kinase-3 beta, PIK-75, halogen bond, inhibitor, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.600 Å )
Citation :

An Unusual Intramolecular Halogen Bond Guides Conformational Selection.

Tesch, R.,Becker, C.,Muller, M.P.  et al.
(2018)  Angew. Chem. Int. Ed. Engl.  57 : 9970 - 9975

PubMed: 29873877
DOI: 10.1002/anie.201804917

Reaction

Chain : B, A
UniProt : P49841 (GSK3B_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+) 2.7.11.26 PubMed:14690523
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L-threonyl-[tau protein] + ATP = O-phospho-L-threonyl-[tau protein] + ADP + H(+) 2.7.11.26 PubMed:14690523
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L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) 2.7.11.1 PubMed:17050006, PubMed:21343617, PubMed:22539723, PubMed:25827072, PubMed:28992046, PubMed:29059170
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L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) 2.7.11.1 PubMed:17050006
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